{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T11:32:06Z","timestamp":1748431926995,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020171","name":"Foreign, Commonwealth and Development Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether, in those requiring continuing uterine stimulation after cervical ripening with oral misoprostol and membrane rupture, augmentation with low\u2010dose oral misoprostol is superior to intravenous oxytocin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Open\u2010label, superiority randomised trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Government hospitals in India.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women who were induced for hypertensive disease in pregnancy and had undergone cervical ripening with oral misoprostol, but required continuing stimulation after artificial membrane rupture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants received misoprostol (25\u2009micrograms, orally, 2\u2010hourly) or titrated oxytocin through an infusion pump. All women had one\u2010to\u2010one care; fetal monitoring was conducted using a mixture of intermittent and continuous electronic fetal monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Caesarean birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 520 women were randomised and the baseline characteristics were comparable between the groups. The caesarean section rate was not reduced with the use of misoprostol (misoprostol, 84\/260, 32.3%, vs oxytocin, 71\/260, 27.3%; aOR\u20091.23; 95%\u2009CI 0.81\u20131.85; <jats:italic>P<\/jats:italic>\u2009=\u20090.33). The interval from randomisation to birth was somewhat longer with misoprostol (225\u2009min, 207\u2013244\u2009min, vs 194\u2009min, 179\u2013210\u2009min; aOR\u20091.137; 95%\u2009CI 1.023\u20131.264; <jats:italic>P<\/jats:italic>\u2009=\u20090.017). There were no cases of hyperstimulation in either arm. The rates of fetal heart rate abnormalities and maternal side effects were similar. Fewer babies in the misoprostol arm were admitted to the special care unit (10 vs 21 in the oxytocin group; aOR\u20090.463; 95%\u2009CI 0.203\u20131.058; <jats:italic>P<\/jats:italic>\u2009=\u20090.068) and there were no neonatal deaths in the misoprostol group, compared with three neonatal deaths in the oxytocin arm. Women's acceptability ratings were high in both study groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Following cervical preparation with oral misoprostol and membrane rupture, the use of continuing oral misoprostol for augmentation did not significantly reduce caesarean rates, compared with the use of oxytocin. There were no hyperstimulation or significant adverse events in either arm of the trial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17839","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T09:48:36Z","timestamp":1715334516000},"page":"1532-1544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oral misoprostol alone, compared with oral misoprostol followed by oxytocin, in women induced for hypertension of pregnancy: A multicentre randomised trial"],"prefix":"10.1111","volume":"131","author":[{"given":"Shuchita","family":"Mundle","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology All India Institute of Medical Sciences  Nagpur Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Lightly","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Liverpool  Liverpool, Merseyside UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5572-8133","authenticated-orcid":false,"given":"Jill","family":"Durocher","sequence":"additional","affiliation":[{"name":"Gynuity Health Projects  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hillary","family":"Bracken","sequence":"additional","affiliation":[{"name":"The Patient\u2010Centered Outcomes Research Institute  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moushmi","family":"Tadas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Government Medical College  Nagpur Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Parvekar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Daga Memorial Women's Government Hospital  Nagpur Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonam Varma","family":"Shivkumar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Mahatma Gandhi Institute of Medical Sciences  Sevagram Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Faragher","sequence":"additional","affiliation":[{"name":"Medical Statistics Unit, Department of Clinical Sciences Liverpool School of Tropical Medicine  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Easterling","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Washington  Seattle Washington State USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Leigh","sequence":"additional","affiliation":[{"name":"Nexus Clinical Analytics Charnock Richard  Lancashire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Liverpool  Liverpool, Merseyside UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarko","family":"Alfirevic","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Liverpool  Liverpool, Merseyside UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly","family":"Winikoff","sequence":"additional","affiliation":[{"name":"Gynuity Health Projects  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Weeks","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University of Liverpool  Liverpool, Merseyside UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"volume-title":"Improving maternal and newborn health and survival and reducing stillbirth: progress report 2023","year":"2023","author":"World Health Organization, United Nations Children's Fund (UNICEF) & United Nations Population Fund","key":"e_1_2_12_2_1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17136"},{"volume-title":"WHO recommendations for induction of labour","year":"2011","author":"World Health Organization","key":"e_1_2_12_4_1"},{"volume-title":"Inducing labour (NICE guideline NG207)","year":"2021","author":"National Institute of clinical and care excellence (NICE)","key":"e_1_2_12_5_1"},{"issue":"6","key":"e_1_2_12_6_1","article-title":"Low\u2010dose oral misoprostol for induction of labour","volume":"6","author":"Kerr RS","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h217"},{"key":"e_1_2_12_8_1","first-page":"1","article-title":"Vaginal misoprostol versus vaginal dinoprostone for cervical ripening and induction of labour: an individual participant data meta\u2010analysis of randomised controlled trials","volume":"00","author":"Patabendige M","year":"2024","journal-title":"BJOG"},{"volume-title":"Reproductive health. Managing complications in pregnancy and childbirth: a guide for midwives and doctors","year":"2017","author":"World Health Organization","key":"e_1_2_12_9_1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(95)02389-T"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.08.009"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2001.00231.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-04009-8"},{"issue":"3","key":"e_1_2_12_14_1","article-title":"Methods for cervical ripening and labour induction in late pregnancy: generic protocol","author":"Hofmeyr GJ","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15397"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31367-3"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2307\/2530245"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.108"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181ed36cc"},{"volume-title":"WHO recommendations for augmentation of labour","year":"2014","author":"World Health Organization","key":"e_1_2_12_20_1"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13354"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xagr.2022.100123"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2023.05.037"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.17839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T16:13:50Z","timestamp":1729095230000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.17839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,10]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/1471-0528.17839"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.17839","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"type":"print","value":"1470-0328"},{"type":"electronic","value":"1471-0528"}],"subject":[],"published":{"date-parts":[[2024,5,10]]},"assertion":[{"value":"2024-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}