{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:36:41Z","timestamp":1788525401554,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008305","name":"Physiotherapy Research Foundation","doi-asserted-by":"publisher","award":["PG17\u2010021"],"award-info":[{"award-number":["PG17\u2010021"]}],"id":[{"id":"10.13039\/501100008305","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the prevalence and severity of pelvic floor disorders (PFD), and the associations between treatment type and PFD, and cancer stage and PFD in patients before and after hysterectomy for gynaecological cancer; and the changes in outcomes over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Longitudinal cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Gynaecological oncology outpatient clinics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Patients undergoing hysterectomy for endometrial, uterine, ovarian or cervical cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were assessed before, and 6\u2009weeks and 3\u2009months after hysterectomy. Changes over time were analysed using generalised estimating equations or linear mixed models. Associations were analysed using logistic regression models and analyses of variance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Incontinence Severity Index, Pelvic Floor Distress Inventory\u2010short form (PFDI\u201020), Female Sexual Function Index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 277 eligible patients, 126 participated. Prevalence rates of PFD were high before (urinary incontinence [UI] 66%, faecal incontinence [FI] 12%, sexual inactivity 73%) and after (UI 59%, FI 14%, sexual inactivity 58%) hysterectomy. Receiving adjuvant therapy led to moderate\u2010to\u2010very severe UI 3\u2009months after surgery compared with surgery only (odds ratio 4.98, 95% CI 1.63\u201315.18). There was no association between treatment type and other PFD, or cancer stage and any PFD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prevalence of PFD was high before and after hysterectomy for gynaecological cancer. Moderate\u2010to\u2010very\u2010severe UI was associated with adjuvant therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17870","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T06:33:25Z","timestamp":1717050805000},"page":"1545-1554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Natural history of pelvic floor disorders before and after hysterectomy for gynaecological cancer"],"prefix":"10.1111","volume":"131","author":[{"given":"Robyn","family":"Brennen","sequence":"first","affiliation":[{"name":"Department of Physiotherapy The University of Melbourne  Parkville Victoria Australia"},{"name":"Monash Health  Cheltenham Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan Yin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy National Cheng Kung University  Tainan Taiwan"},{"name":"Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Denehy","sequence":"additional","affiliation":[{"name":"School of Health Sciences, The University of Melbourne  Parkville Victoria Australia"},{"name":"The Peter MacCallum Cancer Centre  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sze\u2010Ee","family":"Soh","sequence":"additional","affiliation":[{"name":"School of Primary and Allied Health Care, Monash University  Frankston Victoria Australia"},{"name":"School of Public Health and Preventive Medicine, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jobling","sequence":"additional","affiliation":[{"name":"Head of Gynaecology\u2010Oncology, Monash Health  Moorabbin Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orla M.","family":"McNally","sequence":"additional","affiliation":[{"name":"The Peter MacCallum Cancer Centre  Melbourne Victoria Australia"},{"name":"Oncology\/Dysplasia The Royal Women's Hospital  Parkville Victoria Australia"},{"name":"Department of Medicine The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Hyde","sequence":"additional","affiliation":[{"name":"Gynaecological Oncology Mercy Hospital for Women  Heidelberg Victoria Australia"},{"name":"The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Frawley","sequence":"additional","affiliation":[{"name":"School of Health Sciences, The University of Melbourne  Parkville Victoria Australia"},{"name":"The Royal Women's Hospital  Parkville Victoria Australia"},{"name":"Mercy Hospital for Women  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"e_1_2_14_2_1","volume-title":"Worldwide cancer data: global cancer statistics for the most common cancers","author":"World Cancer Research Fund","year":"2018"},{"issue":"4","key":"e_1_2_14_3_1","first-page":"459","article-title":"Pelvic floor disorders in women with gynecologic malignancies: a systematic review","volume":"29","author":"Ramaseshan AS","year":"2018","journal-title":"Int Urogynecol J"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzx012"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzab042"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.14721"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234389"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-021-02576-y"},{"issue":"9","key":"e_1_2_14_9_1","first-page":"2804","article-title":"Urogynaecological symptoms among oncological survivors and impact of oncological treatment on pelvic floor disorders and lower urinary tract symptoms. 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