{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:33:05Z","timestamp":1787801585602,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vascular Ehlers\u2010Danlos syndrome (vEDS) is a hereditary connective tissue disorder associated with an elevated risk of vascular, uterine and digestive complications. Managing pregnancy in this context can be a challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To systematically review the literature data on the complications in pregnancy associated with vEDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search strategy<\/jats:title>\n                    <jats:p>We searched the Pubmed Medline and Embase databases for articles using the following terms \u201cvascular Ehlers\u2010Danlos syndrome\u201d or \u201cvEDS\u201d AND \u201cpregnancy\u201d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection criteria<\/jats:title>\n                    <jats:p>Women with vEDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data collection and analysis<\/jats:title>\n                    <jats:p>We searched the PubMed\u00ae MEDLINE\u00ae database for publications evaluating obstetric outcomes in women with vEDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main results<\/jats:title>\n                    <jats:p>A total of 121 publications were screened, with six (accounting for 412 pregnancies) included in our review. Of the women included in this sample, 30% were infertile. The miscarriage rate was 13.8% (57\/412) and 8.8% of the live births were premature. Obstetric anal sphincter injuries occurred in 11.3% (23\/203) of the deliveries. The maternal mortality rate per pregnancy was 5.7%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Women with vEDS present an elevated risk of uterine rupture, vascular events, digestive events and death during pregnancy. Women appear to be most at risk during the peripartum period; to avoid expulsive efforts, a caesarean section should be scheduled at 37\u2009weeks of gestation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.17893","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T23:24:48Z","timestamp":1719444288000},"page":"1620-1629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Vascular Ehlers\u2010Danlos syndrome and pregnancy: A systematic review"],"prefix":"10.1111","volume":"131","author":[{"given":"Th\u00e9o","family":"Haem","sequence":"first","affiliation":[{"name":"Department of Gynaecology and Obstetrics Centre Hospitalier Universitaire Amiens Picardie  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Benson","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Centre 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