{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:52:46Z","timestamp":1789735966397,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["13192"],"award-info":[{"award-number":["13192"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011851","name":"Kom op tegen Kanker","doi-asserted-by":"publisher","award":["ZKD6005"],"award-info":[{"award-number":["ZKD6005"]}],"id":[{"id":"10.13039\/501100011851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterise pregnant women diagnosed with primary or recurrent cancer who died during pregnancy, during delivery or within 1\u2009year postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A descriptive study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The registry of the International Network on Cancer, Infertility and Pregnancy (INCIP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women diagnosed with cancer during pregnancy between 2000 and 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the INCIP registry database, we compared the characteristics of all women with cancer who died during pregnancy, delivery or within 1\u2009year postpartum with those of all women with cancer who survived the first year postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Maternal and tumour characteristics and obstetrical and neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 2359 women registered in INCIP, there were 131 cases (5.6%) of maternal mortality. Lung cancer (9\/14, 64.3% of all registered women with lung cancer), gastro\u2010oesophageal cancer (13\/21, 61.9%) and acute leukaemia (17\/105, 16.2%) had the highest rates of maternal mortality. Maternal mortality was associated with fewer live births compared with the control group without maternal mortality (99\/131, 75.6%, vs 1952\/2163, 90.0%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), more elective caesarean sections (64\/104, 60.4%, vs 756\/1836, 41.2%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and a lower gestational age at (induced) delivery (34.0 vs 37.1\u2009weeks; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), resulting in more preterm births.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maternal mortality occurred in 5.6% of cancer\u2010in\u2010pregnancy cases and is associated with adverse perinatal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.17894","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T04:59:00Z","timestamp":1719377940000},"page":"1694-1704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Maternal death by cancer in pregnancy: A descriptive study of the International Network on Cancer, Infertility and Pregnancy"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0550-2793","authenticated-orcid":false,"given":"Joosje H.","family":"Heimovaara","sequence":"first","affiliation":[{"name":"Department of Oncology KU Leuven  Leuven Belgium"},{"name":"Department of Gynaecological Oncology, Centre of Gynaecological Oncology Amsterdam Location Antoni van Leeuwenhoek \u2013 Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6891-2255","authenticated-orcid":false,"given":"Evangeline A.","family":"Huis\u00a0in\u00a0\u2019t\u00a0Veld","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, Centre of Gynaecological Oncology Amsterdam Location Antoni van Leeuwenhoek \u2013 Netherlands Cancer Institute  Amsterdam the Netherlands"},{"name":"Princess M\u00e1xima Centre for Paediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8693-7299","authenticated-orcid":false,"given":"Christianne A. R.","family":"Lok","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, Centre of Gynaecological Oncology Amsterdam Location Antoni van Leeuwenhoek \u2013 Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro Cabrera","family":"Garcia","sequence":"additional","affiliation":[{"name":"Hospital Regional de Alta Especialidad de Ixtapaluca (HRAEI) \u2018Reference Clinic for Hemato\u2010Oncological Diseases during Pregnancy CREHER\u2019 Estado de M\u00e9xico  Ixtapaluca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6404-4537","authenticated-orcid":false,"given":"Michael J.","family":"Halaska","sequence":"additional","affiliation":[{"name":"University Hospital Kralovske Vinohrady and 3rd Medical Faculty, Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-6346","authenticated-orcid":false,"given":"Ingrid","family":"Boere","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Erasmus MC Cancer Institute  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3528-2389","authenticated-orcid":false,"given":"Mina Mhallem","family":"Gziri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Cliniques Universitaires St Luc, UCL  Sint\u2010Lambrechts\u2010Woluwe Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5688-2194","authenticated-orcid":false,"given":"Robert","family":"Fruscio","sequence":"additional","affiliation":[{"name":"Clinic of Obstetrics and Gynaecology University of Milan \u2013 Bicocca, Fondazione IRCCS San Gerardo  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9336-6033","authenticated-orcid":false,"given":"Rebecca C.","family":"Painter","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Amsterdam University Medical Centre, Vrije Universiteit  Amsterdam The Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-3367","authenticated-orcid":false,"given":"Elyce","family":"Cardonick","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Cooper University Health Care  Camden New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7760-879X","authenticated-orcid":false,"given":"Marry M.","family":"van den Heuvel\u2010Eibrink","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Centre for Paediatric Oncology  Utrecht the Netherlands"},{"name":"University Medical Centre \u2013 Wilhelmina Children's Hospital  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Masturzo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Turin, Citt\u00e0 Della Salute e Della Scienza, Sant'Anna Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2438-6783","authenticated-orcid":false,"given":"Kristel","family":"Van\u00a0Calsteren","sequence":"additional","affiliation":[{"name":"Division of Fetomaternal Medicine, Department of Obstetrics and Gynaecology UZ Leuven  Leuven Belgium"},{"name":"Department of Development and Regeneration, Unit of Woman and Child KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7142-7605","authenticated-orcid":false,"given":"Lia","family":"van\u00a0Zuylen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Amsterdam University Medical Centre, Cancer Centre Amsterdam Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5452-4905","authenticated-orcid":false,"given":"Frederic","family":"Amant","sequence":"additional","affiliation":[{"name":"Department of Oncology KU Leuven  Leuven Belgium"},{"name":"Department of Gynaecological Oncology, Centre of Gynaecological Oncology Amsterdam Location Antoni van Leeuwenhoek \u2013 Netherlands Cancer Institute  Amsterdam the Netherlands"},{"name":"Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology UZ Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the International Network on Cancer Infertility and Pregnancy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30059-7"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc\u20102020\u2010001776"},{"key":"e_1_2_12_4_1","unstructured":"ICD\u201011 Reference guide.Part 2. 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