{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:41:16Z","timestamp":1787013676576,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A Serous Tubal Intraepithelial Carcinoma (STIC) without concomitant invasive carcinoma is occasionally identified and associated with a high risk of subsequent peritoneal carcinomatosis. Management needs optimisation. This study explores professionals' opinions and clinical practices regarding the diagnosis, counselling, treatment and follow\u2010up of isolated STIC to facilitate clinical decision making and optimise the direction of future research. A secondary aim is to assess international clinical guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Focus group study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Four online sessions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>\n                      International panel (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912 countries) of gynaecologists, gynaecologic oncologists, pathologists and medical oncologists (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200949).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A semi\u2010structured interview guide was used. Two independent researchers analysed transcripts by open and axial coding. Results were organised in domains. Relevant (inter)national guidelines were screened for recommendations regarding isolated STIC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Professionals' opinions and clinical practices regarding isolated STIC management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Regarding pathology, most professionals identified the SEE\u2010FIM protocol as standard of care for high\u2010risk patients, whereas variation exists in the histopathological examination of fallopian tubes in the general population. Confirmation of STIC diagnosis by a specialised pathologist was recommended. Regarding work\u2010up and follow\u2010up after STIC diagnosis, there was variety and discordance. Data on outcomes is limited. As for treatment, chemotherapy and PARP inhibitors were not recommended by most. Eleven guidelines provided limited recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identified recommendations and highlighted knowledge gaps in the diagnosis and management of isolated STIC. Moreover, recommendations in clinical guidelines are limited. There is an agreed need for international collaboration for the prospective registration of isolated STIC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.17919","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T23:29:35Z","timestamp":1721950175000},"page":"1851-1861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Diagnosis and management of isolated serous tubal intraepithelial carcinoma: A qualitative focus group study"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2991-8184","authenticated-orcid":false,"given":"Serena","family":"Negri","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery University of Milan\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Fisch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne A.","family":"de Hullu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7562-9861","authenticated-orcid":false,"given":"Majke","family":"van Bommel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Simons","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joep","family":"Bogaerts","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Consortium STIC focusgroup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosella P. M. G.","family":"Hermens","sequence":"additional","affiliation":[{"name":"Department of IQ Healthcare Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda P.","family":"Steenbeek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1000"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.04.005"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.09.006"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.03.004"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz062"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14902"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02016"},{"issue":"4","key":"e_1_2_13_9_1","article-title":"Population frequency of serous tubal intraepithelial carcinoma (STIC) in clinical practice using SEE\u2010Fim protocol. JNCI cancer","volume":"2","author":"Samimi G","year":"2018","journal-title":"Spectrum"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.08.016"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000180854.28831.77"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14722"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000604"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.238"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31823b8831"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822f58bc"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03244-w"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181c713a8"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-023-06919-8"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzm042"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/0142159X.2014.917165"},{"key":"e_1_2_13_22_1","unstructured":"leven Vig.Eerste hulp bij\u2026FOCUSGROEPEN. Available from:https:\/\/www.gezondleven.be\/files\/gezondheidsbevordering\/Gezond\u2010Leven\u20102018_\u2010Eerste\u2010Hulp\u2010Bij\u2010__\u2010focusgroepen.pdf"},{"key":"e_1_2_13_23_1","unstructured":"IFoGa O.FIGO's Member Societies. Available from:https:\/\/www.figo.org\/figos\u2010member\u2010societies"},{"key":"e_1_2_13_24_1","unstructured":"U N. World Economic Situation and Prospects.2022Available from:https:\/\/www.un.org\/development\/desa\/dpad\/wp\u2010content\/uploads\/sites\/45\/WESP2022_ANNEX.pdf."},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2018.05.046"},{"key":"e_1_2_13_26_1","volume-title":"Forum","author":"Wagner U","year":"2019"},{"key":"e_1_2_13_27_1","first-page":"280","article-title":"Richtlijn erfelijk en familiair ovarium\u2010carcinoom 2015","volume":"13","author":"Mourits M","year":"2016","journal-title":"Ned Tijdschr Oncol"},{"key":"e_1_2_13_28_1","unstructured":"Forening Ng.Eggstokk\u2010 eggleder\/og bukhinnekreft (OC).2022Available from:https:\/\/www.legeforeningen.no\/contentassets\/ffa8e032720842c0a26f201117f0da04\/kap\u20103\u2010eggstokk\u2010eggleder\u2010og\u2010bukhinnekreft.pdf"},{"key":"e_1_2_13_29_1","unstructured":"Gynekologi SFFO.\u00c4ggstockscancer med epitelial histologi.2023Available from:https:\/\/kunskapsbanken.cancercentrum.se\/globalassets\/cancerdiagnoser\/gynekologi\/aggstockscancer\/nationellt\u2010vardprogram\u2010aggstockscancer.pdf"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.09.018"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2022.08.018"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44294-024-00016-0"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.11.015"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.10.017"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-2011-5"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00731-5"},{"key":"e_1_2_13_37_1","unstructured":"Cancer INd.Femmes porteuses d'une mutation de BRCA1 ou BRCA2 \/D\u00e9tection pr\u00e9coce du cancer du sein et des annexes et strat\u00e9gies de r\u00e9duction du risque2017.2023Available from:file:\/\/\/G:\/Downloads\/Plaquette_Femmes_porteuses_d_une%20mutation_de_BRCA1_ou_BRCA2_mel_20170529.pdf"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002296"},{"key":"e_1_2_13_39_1","volume-title":"Cancerul ovarian","author":"S\u0103n\u0103t\u0103\u0163ii M","year":"2019"},{"issue":"3","key":"e_1_2_13_40_1","first-page":"90","article-title":"C\u00e1ncer de ovario 2022","volume":"65","author":"Pozo SD","year":"2022","journal-title":"Progresos de obstet ginecol"},{"key":"e_1_2_13_41_1","unstructured":"Network NNCC.Genetic\/Familial High\u2010Risk Assessment: Breast Ovarian and Pancreatic.2023Available from:https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/genetics_bop.pdf"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.17919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:18:38Z","timestamp":1764166718000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.17919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,25]]},"references-count":40,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/1471-0528.17919"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.17919","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,25]]},"assertion":[{"value":"2024-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}