{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:57:31Z","timestamp":1782514651482,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Assessment of COVID\u201019 vaccine safety in pregnancy using population\u2010based data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Matched case\u2013control study nested in a retrospective cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>April 2021\u2013March 2022, England.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population or Sample<\/jats:title>\n                    <jats:p>All pregnant individuals aged between 18 and 50\u2009years with valid health records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Individuals identified from the national Maternity Services Data Set (MSDS) had their records linked to hospital admission, national COVID\u201019 vaccine and COVID\u201019 testing databases. Matching included participant's age and estimated week of conception. We compared outcomes across multiple COVID\u201019 vaccine exposures using conditional multivariable logistic regression, adjusting for demographic and health characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Adverse pregnancy, maternal and neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>514\u2009013 individuals were included. We found lower odds of giving birth to a baby who was low birthweight (aOR\u2009=\u20090.86, 95% CI: 0.79\u20130.93), preterm (aOR\u2009=\u20090.89, 95% CI: 0.85\u20130.92) or who had an Apgar score &lt;\u20097 at 5\u2009min of age (aOR\u2009=\u20090.89, 95% CI: 0.80\u20130.98) for individuals who received at least one dose of COVID\u201019 vaccine during pregnancy. The odds of admission to intensive care unit during pregnancy were lower in those vaccinated (aOR\u2009=\u20090.85, 95% CI: 0.76\u20130.95). There was no association between vaccination in pregnancy and stillbirth, neonatal death, perinatal death and maternal venous thromboembolism in pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>COVID\u201019 vaccines are safe to use in pregnancy. Our findings generated important information to communicate to pregnant individuals and health professionals to support COVID\u201019 maternal vaccination programmes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.17949","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T04:59:34Z","timestamp":1726462774000},"page":"1882-1893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["COVID\u201019 Vaccine Safety in Pregnancy, A Nested Case\u2013Control Study in Births From April 2021 to March 2022, England"],"prefix":"10.1111","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3291-3416","authenticated-orcid":false,"given":"Anna\u00a0A.","family":"Mensah","sequence":"first","affiliation":[{"name":"UK Health Security Agency  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Stowe","sequence":"additional","affiliation":[{"name":"UK Health Security Agency  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9932-6865","authenticated-orcid":false,"given":"Jennifer\u00a0E.","family":"Jardine","sequence":"additional","affiliation":[{"name":"Women's Health Research Unit, Centre for Public Health and Policy Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freja\u00a0C.\u00a0M.","family":"Kirsebom","sequence":"additional","affiliation":[{"name":"UK Health Security Agency  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1292-3673","authenticated-orcid":false,"given":"Tom","family":"Clare","sequence":"additional","affiliation":[{"name":"UK Health Security Agency  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaghan","family":"Kall","sequence":"additional","affiliation":[{"name":"UK Health Security Agency  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Campbell","sequence":"additional","affiliation":[{"name":"UK Health Security Agency  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Lopez\u2010Bernal","sequence":"additional","affiliation":[{"name":"UK Health Security Agency  London UK"},{"name":"NIHR Health Protection Research Unit in Respiratory Infections Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Andrews","sequence":"additional","affiliation":[{"name":"UK Health Security Agency  London UK"},{"name":"NIHR Health Protection Research Unit in Vaccines and Immunisation London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3320"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2023.101428"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2020-0355"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23107"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18020596"},{"key":"e_1_2_10_7_1","unstructured":"GOV.UK [Internet] \u201cJCVI Issues New Advice on COVID\u201019 Vaccination for Pregnant Women \u201daccessed July 15 2023 https:\/\/www.gov.uk\/government\/news\/jcvi\u2010issues\u2010new\u2010advice\u2010on\u2010covid\u201019\u2010vaccination\u2010for\u2010pregnant\u2010women."},{"key":"e_1_2_10_8_1","unstructured":"GOV.UK [Internet] \u201cPregnant Women Urged to Come Forward for COVID\u201019 Vaccination \u201d2021 accessed July 15 2023 https:\/\/www.gov.uk\/government\/news\/pregnant\u2010women\u2010urged\u2010to\u2010come\u2010forward\u2010for\u2010covid\u201019\u2010vaccination."},{"key":"e_1_2_10_9_1","unstructured":"GOV.UK [Internet] \u201cCOVID\u201019: The Green Book Chapter\u00a014a \u201d2023 accessed July 18 2023 https:\/\/www.gov.uk\/government\/publications\/covid\u201019\u2010the\u2010green\u2010book\u2010chapter\u201014a."},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","unstructured":"F. C. M.Kirsebom N.Andrews A. A.Mensah et\u00a0al. \u201cVaccine Effectiveness Against Mild and Severe Disease in Pregnant Mothers and Their Infants in England [Internet] \u201dmedRxiv2023 https:\/\/doi.org\/10.1101\/2023.06.07.23290978v1.","DOI":"10.1101\/2023.06.07.23290978"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02467-9"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33937-y"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000005100"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2434"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-023-05374-2"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30052-w"},{"key":"e_1_2_10_17_1","unstructured":"Office for National Statistics [Internet] \u201cProvisional Births in England and Wales \u201daccessed September 14 2023 https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/birthsdeathsandmarriages\/livebirths\/articles\/provisionalbirthsinenglandandwales\/2021."},{"key":"e_1_2_10_18_1","unstructured":"NHS Digital [Internet] \u201cHospital Episode Statistics (HES) \u201daccessed July 14 2023 https:\/\/digital.nhs.uk\/data\u2010and\u2010information\/data\u2010tools\u2010and\u2010services\/data\u2010services\/hospital\u2010episode\u2010statistics."},{"key":"e_1_2_10_19_1","unstructured":"NHS Digital [Internet] \u201cImplementing the Maternity Services Data Set (MSDS) v2.0 Tools and Guidance \u201daccessed July 14 2023 https:\/\/digital.nhs.uk\/data\u2010and\u2010information\/data\u2010collections\u2010and\u2010data\u2010sets\/data\u2010sets\/maternity\u2010services\u2010data\u2010set\/tools\u2010and\u2010guidance."},{"key":"e_1_2_10_20_1","unstructured":"NHS England \u201cNational Vaccination Programmes [Internet] \u201daccessed July 17 2023 https:\/\/www.england.nhs.uk\/contact\u2010us\/privacy\u2010notice\/national\u2010flu\u2010vaccination\u2010programme\/."},{"key":"e_1_2_10_21_1","unstructured":"NHS Digital [Internet] \u201cCohorting as a Service (CaaS) \u201daccessed July 17 2023 https:\/\/digital.nhs.uk\/services\/cohorting\u2010as\u2010a\u2010service\u2010caas."},{"key":"e_1_2_10_22_1","unstructured":"Office for National Statistics [Internet] \u201cChild and Infant Mortality in England and Wales \u201daccessed July 18 2023 https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/birthsdeathsandmarriages\/deaths\/bulletins\/childhoodinfantandperinatalmortalityinenglandandwales\/2021."},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead036"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.08.007"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-010-1609-1"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0280284"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7101e1"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2104983"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2022.100410"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00426-1"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2204399"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.7563"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.07.014"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.202604"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00360-5"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.17949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:18:07Z","timestamp":1764166687000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.17949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":34,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/1471-0528.17949"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.17949","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.10.09.23296737","asserted-by":"object"}]},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]},"assertion":[{"value":"2023-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}