{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:29:33Z","timestamp":1792808973932,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2704000"],"award-info":[{"award-number":["2022YFC2704000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the effect of gonadotropin\u2010releasing hormone agonist (GnRHa) pre\u2010treatment on the clinical outcomes of fresh and frozen embryo transfers (ETs and FETs, respectively) in infertile patients with adenomyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study with literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Peking University First Hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>We analysed 413\u2009cycles of 369 women with adenomyosis who underwent ETs or FETs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed logistic regression analysis and meta\u2010analysis to assess the association of GnRHa pre\u2010treatment with the clinical outcomes of ETs and FETs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The live birth rate (LBR) was compared between patients with and without GnRHa pre\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The LBR was higher in the GnRHa pre\u2010treatment group than in the non\u2010GnRHa pre\u2010treatment group in ETs (41.27% vs. 24.32%, <jats:italic>p<\/jats:italic>\u2009=\u20090.034) and FETs (40.36% vs. 20.75%, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). The odds of achieving a live birth of women with GnRHa pre\u2010treatment were 2.65 times higher than that of those without (95% CI: 1.19\u20135.92, <jats:italic>p<\/jats:italic>\u2009=\u20090.017) after adjusting for confounders in ETs. Similarly, the adjusted odds ratio (OR) was 2.43 (95% CI: 1.10\u20135.40, <jats:italic>p<\/jats:italic>\u2009=\u20090.029) in FETs. For the meta\u2010analysis, eight studies met the inclusion criteria; however, only six reported the adjusted ORs. Combination of these six adjusted ORs with our results revealed that the GnRHa pre\u2010treatment group had higher LBRs than the non\u2010GnRHa pre\u2010treatment group (ET: OR 1.71, 95% CI: 1.30\u20132.26, FET: OR 2.61, 95% CI: 1.52\u20134.49).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In women with adenomyosis, GnRHa pre\u2010treatment may be beneficial for LBRs following both ETs and FETs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.18026","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T15:44:47Z","timestamp":1734450287000},"page":"62-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Gonadotropin\u2010Releasing Hormone Agonist Pre\u2010Treatment on Outcomes of Fresh and Frozen Embryo Transfers in Women With Adenomyosis: A Retrospective Cohort Study With Literature Review"],"prefix":"10.1111","volume":"132","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University First Hospital  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hexiang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Unit, Department of Obstetrics and Gynecology Sir Run Shaw Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University First Hospital  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz049"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2006.01.017"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.06.025"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118756754"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00818-6"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2023.04.008"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2017.07.014"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2019.05.003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2020.11.015"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.10.025"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.01.032"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.02.008"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2022.11.009"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-023-01320-0"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.07.027"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00318"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.10.014"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1198779"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-6247"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2013.824960"},{"key":"e_1_2_11_22_1","first-page":"481","article-title":"Pregnancy Outcomes in Women With Adenomyosis, Undergoing Artificial Endometrial Preparation With and Without Gonadotropin\u2010Releasing Hormone Agonist Pretreatment in Frozen Embryo Transfer Cycles: An RCT","volume":"21","author":"Eslami Moayed M.","year":"2023","journal-title":"International Journal of Reproductive BioMedicine"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98918-5"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12535"},{"key":"e_1_2_11_25_1","first-page":"376","article-title":"Chinese Experts' Consensus on Diagnosis and Treatment of Adenomyosis","volume":"55","author":"Europe PMC","year":"2020","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24786"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000251"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der037"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaw057"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental\u20102019\u2010300117"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00970.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2011.12.001"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa038"},{"key":"e_1_2_11_34_1","first-page":"1","article-title":"Structural and Molecular Features of the Endomyometrium in Endometriosis and Adenomyosis","volume":"1","author":"Benagiano G.","year":"2013","journal-title":"Human Reproduction Update"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.04.036"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.06.016"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2021.2000961"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.4103\/GMIT.GMIT_35_18"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S162541"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2024.07.063"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.5653\/cerm.2016.43.3.169"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.609771"},{"key":"e_1_2_11_43_1","first-page":"14313","article-title":"Pregnancy Outcomes and Neonatal Outcomes After Pituitary Down\u2010Regulation in Patients With Adenomyosis Receiving IVF\/ICSI and FET: Results of a Retrospective Cohort Study","volume":"9","author":"Guo S.","year":"2016","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.10.002"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2022.2065906"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.18026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T07:11:13Z","timestamp":1744701073000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.18026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":44,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/1471-0528.18026"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.18026","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,17]]},"assertion":[{"value":"2024-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}