{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:28:19Z","timestamp":1788881299854,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130046"],"award-info":[{"award-number":["82130046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82320108009"],"award-info":[{"award-number":["82320108009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23Y11901400"],"award-info":[{"award-number":["23Y11901400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the benefit of preimplantation genetic testing for aneuploidy (PGT\u2010A) in recurrent implantation failure (RIF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Secondary analysis of a multicentre, randomised, double\u2010blind, placebo\u2010controlled clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Eight academic fertility centres in China, 2018\u20132020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Overall, 485 infertile women aged\u2009&lt;\u200938\u2009years were evaluated. They had a history of two or more unsuccessful embryo transfer cycles with at least three good\u2010quality embryos that had been transferred cumulatively and underwent a single blastocyst transfer with or without PGT\u2010A. Those with thin endometrium or recurrent pregnancy loss were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were categorised into PGT\u2010A and non\u2010PGT\u2010A groups. All pregnancies were followed to delivery. Pregnancy and neonatal outcomes were obtained from obstetric and neonatal medical records. Propensity score matching (PSM) and multivariate logistic regression models were applied to adjust for potential confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>LBR per embryo transfer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result(s)<\/jats:title><jats:p>There was no significant difference in LBR between the PGT\u2010A and non\u2010PGT\u2010A groups both before (39.1% vs. 41.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.760) and after (39.1% vs. 40.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.862) PSM. Unadjusted and adjusted logistic regression models revealed no beneficial effect of PGT\u2010A on LBR per embryo transfer (crude odds ratio: 0.91, 95% confidence interval: 0.49\u20131.69; adjusted odds ratio: 1.04, 95% confidence interval: 0.53\u20132.03). The incidence of maternal and neonatal complications was not significantly different between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with RIF aged\u2009&lt;\u200938\u2009years do not benefit from PGT\u2010A. Thus, factors other than genetic abnormalities may contribute to this clinical conundrum.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.18027","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T13:14:52Z","timestamp":1734354892000},"page":"92-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Preimplantation Genetic Testing for Aneuploidy on Live Birth Rate in Young Women With Recurrent Implantation Failure: A Secondary Analysis of a Multicentre Randomised Trial"],"prefix":"10.1111","volume":"132","author":[{"given":"Hengyu","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-4544","authenticated-orcid":false,"given":"Yao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Lindheim","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Obstetrics and Gynecology Baylor Scott &amp; White  Temple Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9073-8142","authenticated-orcid":false,"given":"Yun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.08.007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoad023"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01948-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03298-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.8.2097"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.05.033"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-022-02461-9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/457913"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoaa021"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01510-0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.01.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1020055"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez229"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2103613"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.5302"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-04630-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2021.1905886"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02645-5"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57739-5"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00519-0"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab014"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1500421"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.10.019"},{"issue":"5","key":"e_1_2_10_25_1","first-page":"769","article-title":"Preimplantation Genetic Testing for Aneuploidy With Comprehensive Chromosome Screening in Patients Undergoing In\u00a0Vitro Fertilization: A Systematic Review and Meta\u2010Analysis","volume":"140","author":"Cheng X.","year":"2022","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.05.014"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey346"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei291"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmad010"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; 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