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Several biomarkers are now available in a point\u2010of\u2010care test format, which provide swift results to support clinical decision\u2010making.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine sensitivity and specificity of available point\u2010of\u2010care tests used for preeclampsia prediction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search Strategy<\/jats:title><jats:p>Systematic searches of databases (PubMed\/Medline, Ovid Embase) from inception till May 2024 were done to identify relevant studies. Selection criteria: we included studies reporting on the diagnostic test accuracy of any point\u2010of\u2010care test for short\u2010term prediction of preeclampsia in the second or third trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Collection and Analysis<\/jats:title><jats:p>Data were extracted using pre\u2010designed template, and statistical analysis was performed to pool sensitivity and specificity and a hierarchal summary receiver operating characteristic curve model was used. Quality of included studies and risk of bias were assessed following the QUADAS\u20102 tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Results<\/jats:title><jats:p>We identified 17 studies that met the inclusion criteria, six of which described the use of glycosylated fibronectin, five with Congo red, two with placental growth factor (PlGF) and one study each investigated nephrin, misfolded protein, CD44\/FKBPL ratio and inositol phosphoglycan\u2010P. Meta\u2010analysis was possible only for glycosylated fibronectin with a pooled sensitivity of 0.80 (95% CI: 0.51\u20130.94) and a specificity of 0.84 (95% CI: 0.71\u20130.93). Five studies were included in meta\u2010analysis, all of which had a low risk of bias on the QUADAS assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that the point\u2010of\u2010care glycosylated fibronectin testing might be beneficial in clinical triage for preeclampsia in an at\u2010risk population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.18040","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T07:27:05Z","timestamp":1733988425000},"page":"414-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Point\u2010of\u2010Care Tests for Preeclampsia: Systematic Review and Meta\u2010Analysis of Diagnostic Test Accuracy 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