{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:01:25Z","timestamp":1790168485620,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1001300"],"award-info":[{"award-number":["2017YFC1001300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271668"],"award-info":[{"award-number":["82271668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401267"],"award-info":[{"award-number":["81401267"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the comprehensive health status of school\u2010age children conceived through assisted reproductive technology (ART) compared to that of those conceived naturally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective cohort study of children conceived through ART.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>First Affiliated Hospital of Nanjing Medical University, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population Sample<\/jats:title><jats:p>One hundred school\u2010age children were enrolled and followed up (51 conceived via ART and 49 naturally conceived (controls)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive health status assessment was performed in children aged 6\u201312\u2009years, including anthropometric measurements, glucose\u2010lipid metabolism, echocardiography, intelligence, behaviour, vision and hearing. Multivariate regression models were used to adjust for sociodemographic and perinatal covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Comprehensive health status of children conceived via ART.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children conceived by ART had similar height, weight, blood pressure, blood glucose and lipid profiles compared to the controls. Echocardiography showed similar cardiac geometric morphology and left\/right ventricular diastolic\u2010systolic function between the two groups. ART children had lower carotid intima\u2010media thickness than controls (0.52\u2009\u00b1\u20090.11 vs. 0.58\u2009\u00b1\u20090.11). Visual acuity, hearing and intellectual and behavioural assessments were similar. An alternating covering test for the eyes showed a higher incidence of abnormal eye movement in the ART group than in the control group (87.76% vs. 68.89%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The similar overall health status of ART\u2010 and naturally conceived children is reassuring for those receiving ART. However, our study shows a possible increase in the incidence of latent exotropia among ART children. Long\u2010term follow\u2010up is warranted to assess the overall health status associated with ART throughout the lifespan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.18044","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T09:24:52Z","timestamp":1736328292000},"page":"8-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comprehensive Health Assessment of School\u2010Age Children Conceived by Assisted Reproductive Technology: A Prospective Cohort Follow\u2010Up Study"],"prefix":"10.1111","volume":"132","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Clinical Center of Reproductive Medicine The First Affiliated Hospital of Nanjing Medical University  Nanjing 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