{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:15:21Z","timestamp":1782774921054,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011110","name":"UCB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014034","name":"Foundation for Research in Rheumatology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014034","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess safety of fertility treatments in women with systemic lupus erythematosus (SLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Data from the multicentre French observational GR2 (Groupe de Recherche sur la Grossesse et les Maladies Rares) study (2014\u2010ongoing).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Seventy\u2010six centres in France.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>All pregnancies in women with SLE enrolled in the GR2 study, conceived before 1 August 2022, with available end\u2010of\u2010pregnancy data and known conception type, were included; that is, 577 spontaneous and 53 assisted pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comparative analysis of spontaneous and assisted pregnancies was conducted. Logistic regression was used to determine if fertility treatments were independently associated with live birth prognosis, adjusting for confounders (e.g., maternal age). Kaplan\u2013Meier analysis compared cumulative incidences of disease flares and adverse pregnancy outcomes (APOs), with confounding factors adjusted using a Cox regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Live birth, disease flares, and APOs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age was older (35.8 vs. 32.3\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20091\u2009\u00d7\u200910\n                      <jats:sup>\u22124<\/jats:sup>\n                      ), and twins were more frequent in assisted pregnancies (5\/50, 10.0% vs. 20\/554, 3.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047). Lupus disease was clinically inactive at baseline in 51 (96.2%) assisted pregnancies (vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009511, 89.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.15), with 35 of 45 (77.8%) having no chronic damage (vs. 448\/513, 87.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.07). The live birth rate was similar between assisted and spontaneous pregnancies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200946, 86.8% vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009505, 87.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.83), with no statistical difference in the incidence of lupus flares and APOs. These results remained consistent after adjusting for confounding factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fertility treatments in women with mostly well\u2010controlled SLE did not appear to increase risks of maternal and neonatal complications, supporting current recommendations.<\/jats:p>\n                    <jats:p>Trial Registration<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrial.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT02450396\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.18050","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T01:59:46Z","timestamp":1734659986000},"page":"614-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety of Fertility Treatments in Women With Systemic Lupus Erythematosus: Data From a Prospective Population\u2010Based Study"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0829-8764","authenticated-orcid":false,"given":"Amandine","family":"Dernoncourt","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne et RECIF Centre Hospitalier Universitaire Amiens\u2010Picardie  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Guettrot\u2010Imbert","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, Centre de r\u00e9f\u00e9rence Des Maladies 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