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Our objective was to assess the cost utility of first\u2010trimester serological CMV screening, compared to screening of high\u2010risk pregnancies and no serological screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A decision\u2010analytic model was created to compare the cost utility of three strategies from a healthcare sector perspective: universal first\u2010trimester serological screening, screening only of high\u2010risk pregnant women (both including antiviral prophylaxis in cases of primary infection) and serological testing triggered by foetal morphological ultrasound (no CMV serological screening).<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Canada.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Hypothetical population of 80\u2009000 pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Probability, expected values and cost estimates were derived from published literature and local hospital and national insurance data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measure<\/jats:title><jats:p>Cost per maternal and infant quality\u2010adjusted life year (QALY) lost.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Universal serological screening was superior to both screening of high\u2010risk women and no screening (utility of \u22120.42, \u22120.63 and\u2009\u2212\u20090.87 QALY lost, respectively). Sensitivity analysis demonstrated that universal screening was the most cost\u2010effective strategy regardless of the incidence of primary infection, the acceptability of amniocentesis and the efficacy of antiviral prophylaxis. In the Monte Carlo analyses, universal serological screening was the most cost\u2010effective option in 96.36% of simulations. Universal serological screening would allow detection of 152 cases of primary maternal CMV infection and would prevent 29 cases of congenital CMV infection annually.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings support the adoption of a population\u2010based prenatal screening programme for the prevention of congenital CMV infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.18080","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T04:44:14Z","timestamp":1738557854000},"page":"805-815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prenatal Screening for <scp>CMV<\/scp> Primary Infection: A Cost\u2010Utility Model"],"prefix":"10.1111","volume":"132","author":[{"given":"Gebrael","family":"El Hachem","sequence":"first","affiliation":[{"name":"School of Public Health Universit\u00e9 de Montr\u00e9al  Montreal Quebec 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