{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:08:00Z","timestamp":1789373280955,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Risk factors for the placental disorders of pregnancy (pre\u2010eclampsia, fetal growth restriction, preterm birth, and stillbirth) are complex, frequently involving the interplay between clinical factors and wider social and environmental determinants of health. Biomarkers modulate the maternal and fetal responses to biological processes that underlie the development of placental disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop a standardised methodology to assess the importance of, and inter\u2010relationships between, candidate risk factors for the various placental disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search Strategy<\/jats:title>\n                    <jats:p>Systematic searches were conducted using Medline, Embase, Health Technology Assessments, Database of Abstracts of Reviews of Effects, Cochrane Library databases, Google Scholar, and reference lists of retrieved papers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection Criteria<\/jats:title>\n                    <jats:p>We deployed a hierarchy of reviews, systematic reviews, and cohort studies with at least 1000 participants (100 for biomarker studies), published in the prior decade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Collection and Analysis<\/jats:title>\n                    <jats:p>We assessed the strengths of association and quality of evidence linking risk factors with individual placental outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We have developed a standardised approach to assess the importance and inter\u2010relatedness of putative risk factors for the placental disorders of pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.18083","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T01:39:29Z","timestamp":1740015569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Standardised Methods for Developing Conceptual Frameworks for Placental Disorders of Pregnancy: Pre\u2010Eclampsia and Stillbirth"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4432-1485","authenticated-orcid":false,"given":"Terteel","family":"Elawad","sequence":"first","affiliation":[{"name":"Royal Free London NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-3014","authenticated-orcid":false,"given":"Mai\u2010Lei Woo","family":"Kinshella","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology BC Children's and Women's Hospital and University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellie","family":"Stokes","sequence":"additional","affiliation":[{"name":"Royal United Hospitals Bath NHS Foundation Trust  Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Pickerill","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology BC Children's and Women's Hospital and University of British Columbia  Vancouver British Columbia Canada"},{"name":"School of Midwifery University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa Dalle","family":"Piagge","sequence":"additional","affiliation":[{"name":"NHS Lothian Foundation School  Edinburgh 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