{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:57:36Z","timestamp":1788872256927,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess obstetric outcomes in pregnant women with \u2018reactive hypoglycaemia\u2019 (RH) during an oral glucose tolerance test (OGTT), defined as a 2\u2010h blood glucose level lower than the fasting value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Two tertiary maternity units in the United Kingdom.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 1498 women with singleton pregnancies attending for an OGTT between April 2019 and July 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Maternal and neonatal outcomes were compared between three groups: gestational diabetes, reactive hypoglycaemia and normal OGTT. Both logistic and linear regression models were used, which adjusted for maternal age at booking, ethnicity, parity and BMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Abdominal circumference &gt;\u200995th centile, polyhydramnios, gestational age at delivery, preterm birth, birthweight, neonatal hypoglycaemia, admission to neonatal unit, perinatal mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1498 women, 26.7% (<jats:italic>n<\/jats:italic>\u2009=\u2009400) had reactive hypoglycaemia, 27.8% (<jats:italic>n<\/jats:italic>\u2009=\u2009417) GDM and 45.4% (<jats:italic>n<\/jats:italic>\u2009=\u2009681) normal GTT. The reactive hypoglycaemia group were twice as likely to develop polyhydramnios compared with both the GDM (OR 2.77, 95% CI 1.40\u20135.50) and control groups (OR 2.47, 95% CI 1.31\u20134.65). Relative to those with GDM, women with reactive hypoglycaemia had a similar mean birthweight (mean difference 59.4\u2009g, <jats:italic>p<\/jats:italic>\u2009=\u20090.06) but were less likely to experience neonatal hypoglycaemia (OR 0.30, 95% CI 0.001\u20130.15) or preterm birth (OR 0.33, 95% CI 0.18\u20130.60). No differences were found in maternal hypertensive disorders, abdominal circumference &gt;\u200995th centile, shoulder dystocia, Apgar &lt;\u20097, cord pH, admission to neonatal unit or perinatal mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with reactive hypoglycaemia in this sample were at risk of adverse outcomes frequently associated with diabetes, including polyhydramnios.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.18105","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T07:56:59Z","timestamp":1740556619000},"page":"927-934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reactive Hypoglycaemia at Glucose Tolerance Test\u2014Another Presentation of Gestational Diabetes: A Multicentre Retrospective Study"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5236-6375","authenticated-orcid":false,"given":"Sana","family":"Rehman","sequence":"first","affiliation":[{"name":"EGA Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salsabeel","family":"Kazi","sequence":"additional","affiliation":[{"name":"EGA Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haashim","family":"Shah","sequence":"additional","affiliation":[{"name":"Cornell University  Ithaca, New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Wallis","sequence":"additional","affiliation":[{"name":"EGA Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradhiki","family":"Mahindra","sequence":"additional","affiliation":[{"name":"EGA Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8287-9271","authenticated-orcid":false,"given":"Bassel H.","family":"Al Wattar","sequence":"additional","affiliation":[{"name":"Comprehensive Clinical Trials Unit, Institute of Clinical Trials and Methodology University College London  London UK"},{"name":"Beginnings Assisted Conception Unit Epsom and St Helier University Hospitals  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Whitten","sequence":"additional","affiliation":[{"name":"EGA Institute for Women's Health University College London  London UK"},{"name":"University College London Hospital NHS Trust  London 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