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Random\u2010effects meta\u2010analysis with the Hartung\u2013Knapp\u2013Sidik\u2013Jonkman method using a framework for studies with few events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Clinical outcomes combining the core outcome set for preeclampsia and WHO's priority outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen trials investigating six candidates were included. In women with preeclampsia, the addition of epigallocatechin gallate (EGCG) to nifedipine may reduce the time needed to achieve blood pressure control (mean difference (MD)\u2009=\u2009\u221214.10\u2009min, 95% CI \u221218.46 to \u22129.74) and increase the time to the next hypertensive crisis (MD\u2009=\u20093.10\u2009h, 95% CI 2.35 to 3.85) compared to nifedipine alone (1 trial, 349 women; low certainty). Similarly, the addition of resveratrol to nifedipine may reduce the time needed to achieve blood pressure control (MD\u2009=\u2009\u221215.50\u2009min, 95% CI \u221219.83 to \u221211.17) and increase the time to the next hypertensive crisis (MD\u2009=\u20092.50\u2009h, 95% CI 2.09 to 2.91) (1 trial, 349 women; low certainty). No differences were observed for other outcomes or candidates (<jats:italic><jats:styled-content style=\"fixed-case\">Salvia miltiorrhiza<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">Bryophyllum pinnatum<\/jats:styled-content><\/jats:italic> , raspberry and cranberry extracts).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ECGC and resveratrol supplements have been investigated for potential effects in managing clinical signs and symptoms of preeclampsia; however, evidence on the clinical and adverse effects of polyphenols is limited and uncertain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.18106","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T15:19:30Z","timestamp":1741706370000},"page":"867-879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Polyphenols for the Prevention or Management of Preeclampsia: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0476-3385","authenticated-orcid":false,"given":"Phi\u2010Yen","family":"Nguyen","sequence":"first","affiliation":[{"name":"Maternal, Child and Adolescent Health Program Burnet Institute  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Sanderson","sequence":"additional","affiliation":[{"name":"Maternal, Child and Adolescent Health Program Burnet Institute  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4164-3702","authenticated-orcid":false,"given":"Maureen","family":"Makama","sequence":"additional","affiliation":[{"name":"Maternal, Child and Adolescent Health Program Burnet Institute  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6262-7220","authenticated-orcid":false,"given":"Kate","family":"Mills","sequence":"additional","affiliation":[{"name":"Maternal, Child and Adolescent Health Program Burnet Institute  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1059-061X","authenticated-orcid":false,"given":"Anne","family":"Ammerdorffer","sequence":"additional","affiliation":[{"name":"Concept Foundation  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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