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Participation rates were high for people of all recorded ethnicities. A <jats:italic>vaginal self\u2010test<\/jats:italic> was undertaken by 95% (2954\/3121, 95% confidence interval [CI] [93.8, 95.4]) of people. HPV was detected in 12.9% (404\/3121, 95% CI [11.8, 14.2]) of people. 95% (384\/404, 95% CI [92.5, 97.0]) of people with HPV detected had follow\u2010up cytology or colposcopy. 2.6% (82\/3121, 95% CI [2.1, 3.2]) had HPV 16\/18 detected, all of whom attended colposcopy. Cytology triage was completed for 92% (276\/301, 95% CI [88.0, 94.3]) of people with non\u201016\/18 HPV types (<jats:italic>HPV other<\/jats:italic>) detected on a <jats:italic>vaginal self\u2010test.<\/jats:italic> This varied by ethnicity and screening history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirms the feasibility of cervical screening with the universal option of a <jats:italic>vaginal self\u2010test<\/jats:italic> and demonstrated a clear preference for the <jats:italic>vaginal self\u2010test<\/jats:italic>. Challenges remain in relation to equitable provision of cytology triage. Ongoing programme monitoring is imperative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>Australia and New Zealand Clinical Trial Register. 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