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The ACTS group received step\u20102 chemotherapy with cyclophosphamide and etoposide (six cycles) and step\u20103 chemotherapy with cyclophosphamide and carboplatin (six cycles). Key endpoints were overall survival (OS), progression\u2010free survival (PFS) and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The main outcome measures were OS, PFS and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 130 enrolled patients, 65 were assigned to the ACTS group and 65 to the control group. The median OS in the ACTS group was 61.2\u2009months, and patients in the ACTS group had a significantly longer PFS than those in the control group (22.2 vs. 9.73\u2009months). The most common grade \u2265\u20093 adverse events were thrombocytopenia and neutropenia. No treatment\u2010related deaths occurred during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Maintenance <jats:styled-content style=\"fixed-case\">ACTS<\/jats:styled-content> Regimen Improved <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> but Not <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> and Showed a Tolerable Safety Profile in Patients Newly Diagnosed With Advanced Ovarian cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.org\">ClinicalTrials.org<\/jats:ext-link> NCT02562365<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.18178","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T10:28:34Z","timestamp":1745836114000},"page":"52-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Maintenance Therapy With Adjuvant Chemotherapy of Three Steps in Patients Newly Diagnosed With Advanced Ovarian Cancer: A Phase <scp>II<\/scp> Randomised Clinical Trial"],"prefix":"10.1111","volume":"132","author":[{"given":"Zhong","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huayin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Fudan University Shanghai Cancer 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