{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:25:50Z","timestamp":1787739950456,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether the combination of antiangiogenic therapy and poly\u2010ADP\u2010ribose polymerase inhibitors (PARPi) can enhance the effectiveness of maintenance therapy in patients with progressive ovarian cancer who are progressing after PARPi maintenance therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single\u2010centre tertiary hospital in Beijing, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Patients treated with combination therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the clinicopathological data of patients with epithelial ovarian cancer. Telephone follow\u2010ups were performed for eligible participants to verify disease progression and survival status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Clinical endpoints included objective response rate (ORR), disease control rate (DCR), time\u2010to\u2010symptomatic progression (TTSP), and progression\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 25 patients were analysed. Overall confirmed ORR was 44%, and the DCR was 68%. The median TTSP was 12.0\u2009months (95% CI: 2.05\u201324.73). In the progression\u2010free interval (PFI) &gt;\u200912\u2009months group (<jats:italic>n<\/jats:italic>\u2009=\u200915), the ORR was 60% (9\/15), and the DCR was 73.3%. In the PFI \u2264\u200912\u2009months group (<jats:italic>n<\/jats:italic>\u2009=\u200910), the ORR was 20% (2\/10), and the DCR was 60%. The median TTSP was not reached in the PFI &gt;\u200912\u2009months group and was 4.0\u2009months (95% CI: 2.988\u20135.012) for the PFI \u2264\u200912\u2009months group. The 6\u2010month progression\u2010free survival rates were 58% and 40%, respectively. Among the 10 patients who received subsequent chemotherapy, seven achieved partial response (PR), and one had stable disease. The respective ORR and DCR values were 70% and 80%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combining antiangiogenic therapy with the original PARPi may benefit patients with ascites\u2010free ovarian cancer and a low tumour burden who experience disease progression following PARPi maintenance therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.18179","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T07:48:14Z","timestamp":1745394494000},"page":"29-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Combination of <scp>PARP<\/scp> Inhibitor and Antiangiogenic Therapy Following Disease Progression in Patients With Epithelial Ovarian Cancer Undergoing <scp>PARP<\/scp> Inhibitor Maintenance Therapy: A Real\u2010World Study"],"prefix":"10.1111","volume":"132","author":[{"given":"Nan","family":"Zhang","sequence":"first","affiliation":[{"name":"Gynecology Department Peking University Cancer Hospital and Institute, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education of People's Republic of China  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Gynecology Department Peking University Cancer Hospital and Institute, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education of People's Republic of China  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunong","family":"Gao","sequence":"additional","affiliation":[{"name":"Gynecology Department Peking University Cancer Hospital and Institute, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education of People's Republic of China  Beijing 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