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A multiple\u2010threshold meta\u2010analysis and standard bivariate meta\u2010analysis were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Results<\/jats:title><jats:p>This meta\u2010analysis included 14 studies comprising 25\u2009528 follicles. Results showed follicle size is predictive for oocyte developmental competence, including oocyte maturity (area under the receiver operation characteristic curve [AUC]: 0.72, 95% confidence interval 0.66\u20130.77; <jats:italic>n<\/jats:italic>\u2009=\u200924\u2009116; follicle size \u2265\u200915\u2009mm), normal fertilisation (0.62, 0.55\u20130.69; <jats:italic>n<\/jats:italic>\u2009=\u200925\u2009321; follicle size \u2265\u200916\u2009mm), blastocyst formation (0.61, 0.53\u20130.69; <jats:italic>n<\/jats:italic>\u2009=\u200912\u2009859; follicle size \u2265\u200915\u2009mm) and good\u2010quality embryo (0.64, 0.54\u20130.71; <jats:italic>n<\/jats:italic>\u2009=\u200916\u2009631; follicle size \u2265\u200916\u2009mm) per oocyte. Based on per mature oocyte or two\u2010pronuclei zygote, follicle size showed little predictive capacity for embryological parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Follicle size could predict oocyte developmental competence with corresponding optimal thresholds identified. However, the benefits for embryological fate may plateau at follicle sizes \u2265\u200915\u201316\u2009mm once the oocytes achieve maturation or fertilisation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.18203","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T04:03:46Z","timestamp":1746504226000},"page":"1378-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictive Value and Optimal Threshold of Follicle Size in <scp>IVF<\/scp>: Systematic Review and Multiple\u2010Threshold Meta\u2010Analysis"],"prefix":"10.1111","volume":"132","author":[{"given":"Shuyue","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, Women and Children's Hospital, School of Medicine Xiamen University  Xiamen China"},{"name":"Xiamen Key Laboratory of Reproduction and Genetics  Xiamen China"},{"name":"School of Medicine Zhejiang University  Hangzhou 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