{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:56:47Z","timestamp":1787061407143,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011033","name":"Thermo Fisher Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016545","name":"Roche Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine whether aspirin delays gestational age at delivery (GAD) in pregnancies with placental dysfunction (PD) phenotypes (preeclampsia [PE], small\u2010for\u2010gestational\u2010age [SGA], placental abruption and\/or stillbirth).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A secondary analysis of a multicentre stepped\u2010wedge cluster randomised trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>18 maternity\/diagnostic units in Asia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>\n                      Singleton pregnancies examined at 11\u201313\n                      <jats:sup>+6<\/jats:sup>\n                      weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A model in which the effect of aspirin is to delay the GAD in pregnancies with PD was developed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>GAD in pregnancies with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Aspirin administration was associated with a significant reduction in PD &lt;\u200932\u2009weeks (adjusted relative risk 0.543, 95% CI: 0.330\u20130.864), with a trend for an increase of PD \u2265\u200932\u2009weeks (test for trend,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.0018). Similar findings were observed individually for PE, SGA and\/or placental abruption. At 24\u2009weeks, the aspirin\u2010induced prolongation of pregnancies with PD was 2.85\u2009weeks (95% CI: 0.44\u20135.40), and this effect was decreased by \u22120.19\u2009weeks (95% CI: \u22120.33 to \u22120.05) for each week of gestation; therefore, at 28 and 32\u2009weeks' gestation, the aspirin\u2010induced prolongation was 2.09 and 1.33\u2009weeks, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this secondary analysis of a cluster randomised trial, women at high risk of PE who are destined to develop a clinical spectrum of PD may benefit from longer pregnancy duration through aspirin administration in early pregnancy. Aspirin may delay the GAD due to PD, particularly benefiting those deliveries that would occur at earlier gestations without aspirin administration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.18211","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:50:02Z","timestamp":1747194602000},"page":"1460-1468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of Aspirin on Timing of Birth in Pregnancies With Clinical Manifestations of Placental Dysfunction: Evidence From a Multicentre Randomised Clinical Trial"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-1435","authenticated-orcid":false,"given":"Ioannis","family":"Papastefanou","sequence":"first","affiliation":[{"name":"Department of Women and Children's Health, School of Life Course and Population Sciences, Faculty of Life Sciences &amp; Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5632-3445","authenticated-orcid":false,"given":"Yunyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Nguyen\u2010Hoang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Fetal Medicine Centre Tam Anh HCMC General Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duy\u2010Anh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hanoi Obstetrics and Gynecology Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh Thuy","family":"Dinh","sequence":"additional","affiliation":[{"name":"Hanoi Obstetrics and Gynecology Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuko K.","family":"Pooh","sequence":"additional","affiliation":[{"name":"CRIFM Prenatal Medical Clinic  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arihiro","family":"Shiozaki","sequence":"additional","affiliation":[{"name":"Toyama University Hospital  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School  Nanjing China"},{"name":"Anhui Women and Children's Medical Center (Hefei Maternal and Child Health Hospital)  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A.","family":"Choolani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Obstetrics and Gynaecology, National University Centre for Women and Children (NUWoC) National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Showa University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchaya","family":"Luewan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung\u2010Yao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine Taiji Clinic  Taipei 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