{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:04:18Z","timestamp":1767924258982,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000667","name":"Obstetric Anaesthetists' Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the national incidence, characteristics, management and outcomes of peripartum hyponatraemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, observational study using United Kingdom (UK) Obstetric Surveillance System (UKOSS) methodology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>192 of the 194 consultant\u2010led obstetric units in UK National Health Service (NHS) hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Peripartum UK obstetric admissions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Units submitted cases monthly to UKOSS (April 2019\u2013September 2020). The case definition was symptomatic hyponatraemia (sodium\u2009&lt;\u2009125\u2009mmol\/L) in labour or\u2009\u2264\u200948\u2009h postpartum, excluding other causes of symptoms. Pre\u2010eclampsia was excluded as a separate aetiology of hyponatraemia and potential cause of symptoms. As symptom documentation varied, characteristics, management and outcomes were compared between cases with and without reported symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Demographics, symptoms, labour details, management and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty cases were submitted. We excluded 23 cases (10 with sodium\u2009\u2265\u2009125\u2009mmol\/L and 13 with pre\u2010eclampsia). A further 25 had sodium &lt;\u2009125\u2009mmol\/L with no symptoms documented. Thirty\u2010two met the UKOSS definition, resulting in an estimate of 3.0 cases of peripartum hyponatraemia with documented symptoms per 100\u2009000 maternities (95% confidence interval 2.0\u20134.1), using a national estimate of 1\u2009050\u2009915 maternities across the study period. Characteristics and outcomes of cases with and without documented symptoms had some variation; 53% versus 24% had critical care admissions, 41% versus 40% had neonatal unit admissions, and 38% versus 20% had spontaneous vaginal birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Peripartum hyponatraemia was associated with maternal morbidity. Neonatal morbidity and operative birth were high, even without documented maternal symptoms. Poor recognition and documentation of symptoms have likely underestimated the incidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.18247","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:04:54Z","timestamp":1749791094000},"page":"1502-1513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Incidence, Characteristics, Management and Outcomes of Peripartum Hyponatraemia in the United Kingdom: A Prospective Study Using the <scp>UK<\/scp> Obstetric Surveillance System (<scp>UKOSS<\/scp>)"],"prefix":"10.1111","volume":"132","author":[{"given":"Arani","family":"Pillai","sequence":"first","affiliation":[{"name":"Department of Anaesthesia Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila J.","family":"Tata","sequence":"additional","affiliation":[{"name":"Lifespan and Population Health Unit\/Centre for Perinatal Research, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuala","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia London North West University Healthcare NHS Trust  Harrow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zo\u00eb","family":"Vowles","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Department of Women and Children's Health, School of Life Course and Population Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9311-1196","authenticated-orcid":false,"given":"Catherine","family":"Nelson\u2010Piercy","sequence":"additional","affiliation":[{"name":"Lifespan and Population Health Unit\/Centre for Perinatal Research, School of Medicine University of Nottingham  Nottingham UK"},{"name":"Department of Women and Children's Health Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1446517"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-289X(98)80032-0"},{"issue":"2","key":"e_1_2_12_4_1","first-page":"212","article-title":"Water Intoxication Complicating Elective Induction of Labor at Term. 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