{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T01:33:39Z","timestamp":1764898419287,"version":"3.46.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine if routine administration of antenatal corticosteroids affects the risk of infant lower respiratory tract infection and\/or childhood asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Linked population\u2010based cohort analysed using a regression discontinuity design, which better controls for confounding than standard observational studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>British Columbia, Canada.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Singleton pregnancies with a maternal admission for delivery between 31\u2009+\u20090 and 36\u2009+\u20096\u2009weeks' gestation from 2000 to 2016, with follow\u2010up to 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We estimated if risks of childhood respiratory outcomes differed between pregnancies admitted just before the Canadian recommended clinical cut\u2010off for antenatal corticosteroid administration of 34\u2009+\u20090\u2009weeks gestation (i.e., with higher probability of exposure to antenatal corticosteroids; \u2018exposed\u2019) than those admitted just after this cut\u2010off (i.e., with lower probability of exposure; \u2018unexposed\u2019) using log binomial regression (infant lower respiratory infection hospitalisation) and pooled log binomial regression (asthma).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Infant lower respiratory tract infection hospitalisation, inpatient or outpatient asthma diagnosis at 1\u201318\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In our cohort of 21\u2009965 children, 412 (1.9%) infants were hospitalised with a lower respiratory tract infection and 2287 (10.4%) were diagnosed with asthma. Routine administration of antenatal corticosteroids was not associated with infant lower respiratory tract infection (risk ratio\u2009=\u20090.95 [95% CI: 0.61, 1.37], risk difference\u2009=\u2009\u22120.15 excess cases per 100 [95% CI: \u22121.30, 0.99]) or childhood asthma (rate ratio\u2009=\u20091.08 [95% CI: 0.88, 1.24]\u00a05.49 excess cases per 100\u2009by age 13 years [95% CI: \u22121.78, 14.39]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found no evidence that routine administration of antenatal corticosteroids affects the risk of later childhood respiratory illnesses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.18252","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:10:26Z","timestamp":1749791426000},"page":"263-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antenatal Corticosteroid Administration and Childhood Respiratory Morbidity: A Regression Discontinuity Study"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0502-3423","authenticated-orcid":false,"given":"Jennifer A.","family":"Hutcheon","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Harper","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Occupational Health McGill University  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Claire","family":"Cordingley","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Liauw","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Amanda","family":"Skoll","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6640-8672","authenticated-orcid":false,"given":"Peter M.","family":"Socha","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Occupational Health McGill University  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Srour","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and of Neurology and Neurosurgery McGill University  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph Y.","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Alberta  Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin C.","family":"Strumpf","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Occupational Health McGill University  Montreal Canada"},{"name":"Department of Economics McGill University  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2016.05.011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-312333"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.06.023"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14271"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.2228"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516783"},{"issue":"12","key":"e_1_2_10_8_1","article-title":"Antenatal Corticosteroids for Accelerating Fetal Lung Maturation for Women at Risk of Preterm Birth","volume":"12","author":"McGoldrick E.","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.04.007"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1718573"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.4303"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000748"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17027"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17611"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-0757-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002057"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.045971"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.051763"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)81009-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-303157"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2013.69"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770900802262795"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2010.002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyab204"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13754"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2009.238"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.01.030"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12436"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5407"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000138"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5293"},{"issue":"3","key":"e_1_2_10_32_1","first-page":"939","article-title":"Strategies for Evaluating the Assumptions of the Regression Discontinuity Design: A Case Study Using a Human Papillomavirus Vaccination Programme","volume":"46","author":"Smith L. 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