{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:52:14Z","timestamp":1777711934850,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011272","name":"FP7 Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effects of aspirin on the distribution of birthweight and its impact on the rates of large\u2010for\u2010gestational\u2010age (LGA) neonates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Secondary analysis of the Combined Multimarker Screening and Randomised Patient Treatment with Aspirin for Evidence\u2010based Preeclampsia Prevention (ASPRE) trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Thirteen hospitals in England, Spain, Belgium, Greece, Italy and Israel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Participants of the ASPRE trial at increased risk of preterm pre\u2010eclampsia (PE) who had a live birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared the birthweight distributions and the rates of LGA neonates between the trial groups. Analyses were stratified according to the presence of pre\u2010existing diabetes mellitus and the development of PE, and logistic regression was used to investigate independent predictors of LGA neonates with birthweight above the 90th percentile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Birthweight distribution and rates of LGA neonates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1571 singleton, live neonates (777 from the aspirin group and 794 from the placebo group), aspirin was associated with a shift in birthweight from &lt;\u20092500 to 2500\u20134000\u2009g, and birthweight percentile from &lt;\u200925th to 25th\u201475th percentiles, with no significant increase in LGA neonates (5.5% vs. 6.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.667). Logistic regression demonstrated a significant interaction between treatment and pre\u2010existing diabetes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value 0.034), and a positive association between maternal weight and LGA neonates (adjusted odds ratio 1.040, 95% confidence interval 1.030\u20131.051,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aspirin use is associated with increased birthweight without increasing the rate of LGA neonates. Among women with pre\u2010existing diabetes, aspirin may be associated with a higher rate of LGA neonates, warranting further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.18263","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T04:13:58Z","timestamp":1751343238000},"page":"1606-1614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aspirin, Birthweight, and Large\u2010For\u2010Gestational\u2010Age Neonates: A Secondary Analysis of the\n                    <scp>ASPRE<\/scp>\n                    Trial"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-3592","authenticated-orcid":false,"given":"Daniel L.","family":"Rolnik","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Monash University  Clayton Victoria 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