{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:18:37Z","timestamp":1784330317404,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004690","name":"Minist\u00e8re de la Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the association between maternal haemoglobinaemia in the immediate post\u2010partum period and PPD symptoms 2\u2009months after vaginal delivery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Ancillary cohort study of the TRAAP trial, a multicentre trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>In France, 2015\u20132016.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Women with a singleton pregnancy and vaginal delivery \u2265\u200935\u2009weeks. We excluded women with known psychiatric conditions and those who were non\u2010respondent to the Edinburgh Post\u2010partum Depression Scale (EPDS) questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The exposure was immediate post\u2010partum haemoglobinemia (systematically collected in TRAAP trial) as a continuous variable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome<\/jats:title>\n                    <jats:p>PPD symptoms at 2\u2009months post\u2010partum, defined as an EPDS score \u2265\u200911. We also differentiated two levels of PPD symptom severity: moderate (11\u2009\u2264\u2009EPDS\u2009&lt;\u200913) and severe (EPDS\u2009\u2265\u200913) depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Amongst the 2672 women included, 1115 (43.6%) had post\u2010partum anaemia (haemoglobin &lt;\u200911\u2009g\/dL) in the immediate post\u2010partum and 369 (13.8%) had PPD symptoms at 2\u2009months. The relation between haemoglobin and PPD symptoms was linear. In the multivariable analysis, each 1\u2009g\/dL increase in haemoglobin level was associated with a 9% decrease in the risk of post\u2010partum depression symptoms (adjusted Relative Risk 0.91; 95% CI 0.82\u20130.997). Post\u2010partum haemoglobin was specifically associated with moderate depressive symptoms (adjusted Relative Risk 0.84; 95% CI, 0.72\u20130.98) but not with severe depressive symptoms (aRR 0.95; 95% CI, 0.84\u20131.07).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In women with vaginal delivery, each 1\u2009g\/dL increase in haemoglobin level was associated with a 9% decrease in the risk of post\u2010partum depression symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.18289","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T07:58:18Z","timestamp":1752479898000},"page":"1644-1654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Post\u2010Partum Anaemia and Depressive Symptoms at Two Months After Vaginal Delivery: A Secondary Analysis of the\n                    <scp>TRAAP<\/scp>\n                    Trial"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0539-3752","authenticated-orcid":false,"given":"Lola","family":"Loussert","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Institut Sant\u00e9 Des Femmes, Centre for Research in Epidemiology and Statistics (CRESS) U1153, Obstetrical Perinatal and Pediatric Epidemiology Research Team (Epop\u00e9), INSERM, INRAE  Paris France"},{"name":"Department of Obstetrics and Gynecology Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Sentilhes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Bordeaux University Hospital  Bordeaux 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Epidemiology Research Team (Epop\u00e9), INSERM, INRAE  Paris France"},{"name":"Department of Anesthesiology and Intensive Care Medicine, Armand Trousseau Hospital, DMU DREAM, GRC 29, Assistance Publique\u2010H\u00f4pitaux de Paris Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0269-4600","authenticated-orcid":false,"given":"Sarah","family":"Tebeka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Louis Mourier Hospital  Colombes France"},{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM UMR1266, Institute of Psychiatry and Neuroscience of Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6561-3321","authenticated-orcid":false,"given":"Catherine","family":"Deneux\u2010Tharaux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Institut Sant\u00e9 Des Femmes, Centre for Research in Epidemiology and Statistics (CRESS) U1153, Obstetrical Perinatal and Pediatric Epidemiology Research Team (Epop\u00e9), INSERM, INRAE  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the TRAAP study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.4363"},{"issue":"3","key":"e_1_2_12_3_1","article-title":"Prevalence and Risk Factors for Postpartum Depression 2 Months After a Vaginal Delivery: A Prospective Multicenter Study","volume":"230","author":"Froeliger A.","year":"2023","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15424"},{"issue":"4","key":"e_1_2_12_5_1","first-page":"185","article-title":"Maternal Mortality in France, 2016\u20102018, Frequency, 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