{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:48:25Z","timestamp":1780548505172,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001279","name":"Great Ormond Street Hospital Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009471","name":"Stiftelsen Dam","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n Hirschsprung is a congenital disorder affecting the gastrointestinal tract. However, pelvic colorectal surgery in infancy has been hypothesised to impact gynaecological outcomes in later life. Describe sexual function and fertility outcomes in women with Hirschsprung disease compared to population controls. Assess factors associated with poor outcomes (sexual dysfunction and subfertility).<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n International multicentre cross\u2010sectional cohort study with comparison to controls from the general population.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Status post\u2010discharge from paediatric services.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n Female patients aged >\u200920\u2009years.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Validated questionnaire\u2010based survey with linkage to patient medical records. Comparison with controls using univariate analyses.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n Sexual dysfunction (Female Sexual Function Index; FSFI \u2264\u200926), Subfertility at 1 and 2\u2009years.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sexual dysfunction as per the FSFI was more common in patients and associated with poor functional outcomes; sexual abstinence seemed to associate even more so with poor bowel outcomes. Subfertility was higher in patients compared to controls (1\u2009year: 21\/45 (47%) vs. 38\/178 (21%),\n p<\/jats:italic>\n \u2009=\u20090.0008; 2\u2009years: 12\/45 (27%) vs. 17\/178 (10%),\n p<\/jats:italic>\n \u2009=\u20090.004). There was an increased proportion of patients who had accessed fertility services (20\/45 (44%) vs. 43\/178 (24%);\n p<\/jats:italic>\n \u2009=\u20090.009), the proportion of successful pregnancies in patients attempting to conceive with IVF (11\/17 (65%) vs. 27\/43 (63%);\n p<\/jats:italic>\n \u2009=\u20091.0) was similar.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n These novel data suggest that women with Hirschsprung disease who have undergone reconstructive surgery may be at risk for adverse sexual function and fertility outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.18294","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T10:09:01Z","timestamp":1752142141000},"page":"1673-1680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impaired Fertility and Sexual Function in Women With Hirschsprung Disease: Results From an International Multi\u2010Centre Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3303-6320","authenticated-orcid":false,"given":"Joseph R.","family":"Davidson","sequence":"first","affiliation":[{"name":"Great Ormond Street Hospital for Children London UK"},{"name":"UCL Great Ormond Street Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Mutanen","sequence":"additional","affiliation":[{"name":"New Children's Hospital Helsinki Finland"},{"name":"University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L\u00f6f","family":"Granstr\u00f6m","sequence":"additional","affiliation":[{"name":"Karolinska University Hospital Stockholm Sweden"},{"name":"Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders Telle","family":"Hoel","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros P.","family":"Loukogeorgakis","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children London UK"},{"name":"UCL Great Ormond Street Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"De Coppi","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children London UK"},{"name":"UCL Great Ormond Street Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Bj\u00f8rnland","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Oslo Norway"},{"name":"University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Wester","sequence":"additional","affiliation":[{"name":"Karolinska University Hospital Stockholm Sweden"},{"name":"Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Eaton","sequence":"additional","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko P.","family":"Pakarinen","sequence":"additional","affiliation":[{"name":"New Children's Hospital Helsinki Finland"},{"name":"University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Curry","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children London 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