{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:18:38Z","timestamp":1789172318920,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate factors associated with first\u2010time preeclampsia in second pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Population\u2010based cohort study using Swedish national registers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Sweden 1992\u20132019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>A group of 808\u2009107 women with second singleton deliveries, who did not have preeclampsia in first pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Information in the Swedish Medical Birth Register, relating to (1) first pregnancy complications, (2) maternal characteristics in early second pregnancy, and (3) interpregnancy changes in risk factor status, was examined for association with first\u2010time preeclampsia occurring in second pregnancy using modified Poisson regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>First\u2010time preeclampsia, and first\u2010time preeclampsia with preterm delivery (&lt;\u200937 gestational weeks) in second pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adjusted relative risks (aRRs; 95% confidence interval) for first\u2010time preeclampsia in second pregnancy increased after first pregnancy complications, including: gestational hypertension (4.61; 4.20, 5.05) and preterm delivery (1.99; 1.87, 2.12). There was a dose\u2010dependent association between interpregnancy weight change and risk of first\u2010time preeclampsia in second pregnancy. Compared to stable weight (BMI \u22121 to 1 unit) a 2 to 4 BMI unit increase was associated with a 50% increase in risk of first\u2010time preeclampsia (1.57; 1.47, 1.67), and weight loss equivalent to &gt;\u20092 BMI units was associated with a reduced risk (0.63, 0.55, 0.72). This pattern of association was consistent also when stratifying by first pregnancy BMI (18.5 to &lt;\u200925, 25 to &lt;\u200930, 30 or above).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In addition to maternal disease and complication in first pregnancy, interpregnancy weight change was also associated with increased risks of first\u2010time preeclampsia in second pregnancy, even in women with normal weight in first pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.18348","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T07:44:00Z","timestamp":1756712640000},"page":"154-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal and Interpregnancy Factors and Risks of First\u2010Time Preeclampsia in Second Pregnancy: A Swedish National Cohort Study"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4362-7762","authenticated-orcid":false,"given":"Hanna","family":"Carr","sequence":"first","affiliation":[{"name":"Clinical Epidemiology Division, Department of Medicine Karolinska Institutet  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Johansson","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division, Department of Medicine Karolinska Institutet  Solna Sweden"},{"name":"Department of Women's Health Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Snowden","sequence":"additional","affiliation":[{"name":"School of Public Health Oregon Health &amp; Science University\u2014Portland State University  Portland Oregon 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