{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:10:47Z","timestamp":1781151047654,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZZYSM202211006"],"award-info":[{"award-number":["SZZYSM202211006"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endometriosis (EMs) is a common gynaecological condition with high recurrence rates after fertility\u2010preserving laparoscopic surgery, and optimal postoperative medical treatment remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of various postoperative medical treatments in reducing recurrence, pain and adverse events in EMs patients after fertility\u2010preserving surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search Strategy<\/jats:title>\n                    <jats:p>PubMed, Web of Science, CENTRAL and Embase databases searched until August 1, 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection Criteria<\/jats:title>\n                    <jats:p>Randomised controlled trials (RCTs) involving women aged 20\u201345\u2009years post\u2010fertility\u2010preserving laparoscopic surgery, comparing single postoperative medications with a minimum follow\u2010up of 2\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Collection and Analysis<\/jats:title>\n                    <jats:p>Two reviewers independently extracted data and assessed quality using ROB 2.0 and CINeMA. Bayesian network meta\u2010analysis calculated odds ratios (OR) and mean differences (MD) for recurrence rates, VAS pain reduction and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Results<\/jats:title>\n                    <jats:p>\n                      Sixteen RCTs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091605 participants) evaluated 10 drugs: danazol, desogestrel, dienogest, gestrinone, goserelin, leuprolide, LNG\u2010IUS, medroxyprogesterone, oral contraceptives and triptorelin. Only LNG\u2010IUS significantly reduced recurrence rates (OR 0.12, 95% CI 0.02\u20130.63) and showed the greatest reduction in VAS pain scores (MD \u221224.96, 95% CI \u221241.76 to \u22128.75). Danazol significantly increased weight gain, and goserelin increased hot flashes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LNG\u2010IUS combined with laparoscopic surgery appears most effective in reducing recurrence and pain in EMs patients. Danazol and goserelin should be used cautiously due to notable adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.70016","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:47:37Z","timestamp":1759135657000},"page":"253-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness and Safety of Postoperative Medical Treatments Following Fertility\u2010Preserving Surgery for Endometriosis: A Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"133","author":[{"given":"Yi","family":"Xiong","sequence":"first","affiliation":[{"name":"Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenrui","family":"Huang","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Ma","sequence":"additional","affiliation":[{"name":"Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufang","family":"Jin","sequence":"additional","affiliation":[{"name":"Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Lin","sequence":"additional","affiliation":[{"name":"Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Deng","sequence":"additional","affiliation":[{"name":"Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfeng","family":"Peng","sequence":"additional","affiliation":[{"name":"Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchang","family":"Huang","sequence":"additional","affiliation":[{"name":"Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Du","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0751-797X","authenticated-orcid":false,"given":"Xia","family":"Han","sequence":"additional","affiliation":[{"name":"Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.16466"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1000274"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.18066"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp007"},{"key":"e_1_2_12_6_1","volume-title":"Network Meta\u2010Analysis of the Efficacy and Safety of Different Drug Treatments Following Fertility\u2010Preserving Surgery for Endometriosis","author":"Zheng Y.","year":"2020"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoac009"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa033"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-022-06862-0"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16366"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmac040"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14621"},{"issue":"4","key":"e_1_2_12_13_1","first-page":"807","article-title":"Chinese Herbal Medicine, Alter\u2010 Native or Complementary, for Endometriosis\u2010Associated Pain: A Meta\u2010Analysis","volume":"51","author":"Ma Y.","year":"2023","journal-title":"Archives of Gynecology and Obstetrics"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000529400"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14\u20102385"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003082"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cl2.1080"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102015\u2010010919"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X12455847"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1044"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.03.016"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224\u2010018\u20101119\u20103"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.5.1335"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.11.2399"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2021.1929151"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12633"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2017.6399"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.10.022"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13677"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.34172\/aim.2021.96"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1296124"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31824264c3"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13023"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0015\u20100282(03)00608\u20103"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479\u2010828X.2010.01152.x"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.12.020"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02836527"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28579"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh869"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.044"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.70016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T01:20:21Z","timestamp":1764897621000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.70016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/1471-0528.70016"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.70016","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"2025-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}