{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:56:42Z","timestamp":1790553402164,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018688","name":"Korea Disease Control and Prevention Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201000558188"],"award-info":[{"award-number":["RS\u20102025\u201000558188"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002507","name":"Kangwon National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NO.RS\u20102021\u2010II211343"],"award-info":[{"award-number":["NO.RS\u20102021\u2010II211343"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","award":["800\u201020250251"],"award-info":[{"award-number":["800\u201020250251"]}],"id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether genetic predisposition to pre\u2010eclampsia (PE), measured by a polygenic risk score (PRS), is associated with incident hypertension and cardiovascular disease (CVD) after delivery in Asian women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective population\u2010based cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Data were utilised from the Korean Genome and Epidemiology Study and additional multicentre cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>35\u2009872 parous Korean women aged 40\u201380\u2009years at last surveillance, with genotype data, no history of hypertension or CVD before delivery, and complete clinical information. For external validation, 559 parous Korean women were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The PE\u2010PRS was calculated for Asian women, and the study population was divided into the high PE\u2010PRS and low PE\u2010PRS groups. The long\u2010term risks of incident hypertension and CVD (ischaemic heart disease or stroke) after delivery were compared between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Incident hypertension and CVD after delivery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Women in the high PE\u2010PRS group had an increased risk of developing hypertension (adjusted hazard ratio [aHR] 1.25, 95% CI 1.17\u20131.34) and ischaemic heart disease (aHR 1.28, 95% CI 1.07\u20131.54) compared to the low PE\u2010PRS group. The risk of hypertension was highest among women with both a history of PE and a high PE\u2010PRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Genetic predisposition to PE, as measured by the PE\u2010PRS, is associated with an elevated risk of incident hypertension and ischaemic heart disease in Asian women. These findings suggest the potential utility of the PE\u2010PRS as a complementary tool in assessing individualised hypertension risk in parous women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.70072","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T14:03:40Z","timestamp":1763129020000},"page":"662-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polygenic Risk for Pre\u2010Eclampsia and the Long\u2010Term Risk of Incident Hypertension and Cardiovascular Disease: A Population\u2010Based Cohort Study"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0615-4452","authenticated-orcid":false,"given":"Eun\u2010Saem","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4116-3327","authenticated-orcid":false,"given":"Sang\u2010Hyuk","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics Kangwon National University College of Medicine  Chuncheon Republic of Korea"},{"name":"Interdisciplinary Graduate Program in Medical Bigdata Convergence Kangwon National University  Chuncheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Mi","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Seoul National University Bundang Hospital  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan\u2010Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of 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