{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:13:41Z","timestamp":1791828821183,"version":"4.3.4"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess whether Er:YAG laser is superior to sham in treating women with mild\/moderate stress urinary incontinence (SUI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A single blinded, multi\u2010centre RCT comparing Er:YAG laser to sham in women with mild\/moderate SUI with patients blinded to allocated treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Three urogynaecology departments in United Kingdom, Switzerland and Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population or Sample<\/jats:title>\n                    <jats:p>79 participants were recruited with mild\/moderate SUI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were randomised (2 active: 1 sham) receiving 3 treatment sessions. Participants were assessed at baseline and 6\u2009months post final treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Primary outcome measure: cure defined as at least 50% reduction in 1\u2009h pad weigh test (PWT) at 6\u2009months compared to baseline (as per FDA guidelines). Secondary Outcomes: Change in PWT, (ICIQ\u2010UI SF), (PISQ\u201012), cough test standing and supine and visual analogue score for pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      32\/51 patients (62.7%) of patients were defined as cured (per FDA guidelines) in the laser group compared with 4\/23 (18.2%) cure in the sham group,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, (OR 7.6, 2.2\u201325.8 95% CI). There was a statistically and clinically significant improvement in patients treated with laser in PWT, ICIQ\u2010UI SF and PISQ\u201012 at 6\u2009months (3\u2009g,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002, 5 points,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and 6 points,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively). There was no evidence of statistically significant differences in the sham group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This RCT demonstrates a beneficial effect of Er:YAG laser in women with mild\/moderate SUI compared with sham.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link>\n                      (NCT03996070)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.70080","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T10:34:01Z","timestamp":1762943641000},"page":"609-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Vaginal Erbium Laser for the Treatment of Mild\u2010to\u2010Moderate Stress Urinary Incontinence: A Multicentre Randomised Sham\u2013Controlled Trial"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-6200","authenticated-orcid":false,"given":"Christian","family":"Phillips","sequence":"first","affiliation":[{"name":"Hampshire Hospitals Foundation Trust Urogynaecology  Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetika","family":"Shah","sequence":"additional","affiliation":[{"name":"Hampshire Hospitals Foundation Trust Urogynaecology  Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8235-1239","authenticated-orcid":false,"given":"Marianne","family":"Gamper","sequence":"additional","affiliation":[{"name":"Kantonsspital Urogynaecology  Frauenfeld Switzerland"},{"name":"Blasenzentrum der Frau AG  Frauenfeld Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Kuszka","sequence":"additional","affiliation":[{"name":"Hochtaunus Kliniken  Bad Homburg Germany"},{"name":"Department of Gynecology Southwest Medical University  Luzhou Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kandiah","family":"Chandrakumaran","sequence":"additional","affiliation":[{"name":"Hampshire Hospitals Foundation Trust Urogynaecology  Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Viereck","sequence":"additional","affiliation":[{"name":"Kantonsspital Urogynaecology  Frauenfeld Switzerland"},{"name":"Blasenzentrum der Frau AG  Frauenfeld Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192\u2010009\u20100976\u20109"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.L1842"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14927"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2023.05.014"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23402"},{"issue":"1","key":"e_1_2_11_7_1","first-page":"1","article-title":"Dual Tissue Regeneration: Non\u2010Ablative Resurfacing of Soft Tissues With FotonaSmooth Mode Er: YAG Laser","volume":"2018","author":"Lukac M.","year":"2018","journal-title":"Journal of Laser and Health Academy"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000401"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2017.01.012"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjab299"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517\u2010017\u20103650\u20100"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517\u2010017\u20103784\u20100"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2015.1078668"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.03.034"},{"key":"e_1_2_11_15_1","first-page":"67","article-title":"Minimally Invasive Laser Procedure for Early Stages of Stress Urinary Incontinence","volume":"1","author":"Fistonic I.","year":"2012","journal-title":"Journal of the Laser and Health Academy"},{"issue":"2","key":"e_1_2_11_16_1","first-page":"97","article-title":"Short\u2010Term Effect of Vaginal Erbium Laser on the Genitourinary Syndrome of Menopause","volume":"67","author":"Gambacciani M.","year":"2015","journal-title":"Minerva Ginecologica"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22416"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-1884-0"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2015.1071126"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.06.031"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2016.09.012"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2170-5"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-016-3129-y"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13051377"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2445-x"},{"key":"e_1_2_11_26_1","unstructured":"https:\/\/www.nice.org.uk\/guidance\/ipg696\/documents\/321#:~:text=The%20procedure 2.3%20Transvaginal%20laser&text=A%20laser%2Dprobe%20device%20is 4%20to%206%20weeks%20apart."},{"key":"e_1_2_11_27_1","first-page":"587","article-title":"The Use of Energy\u2010Based Devices for the Treatment of Stress Urinary Incontinence: A Systematic Review of Literature and Meta\u2010Analysis of Randomised Control Trials","volume":"6","author":"Shah G.","year":"2024","journal-title":"Urogynaecology"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-04247-1"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-019-04148-9"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.15222"},{"key":"e_1_2_11_31_1","unstructured":"\u201cGuidance for Industry and Food and Drug Administration Staff\u2014Clinical Investigations of Devices Indicated for the Treatment of Urinary Incontinence \u201dhttps:\/\/www.fda.gov\/media\/71054\/download."},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22436"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20379"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-003-1063-2"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2019.08.004"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-014-2342-9"},{"key":"e_1_2_11_37_1","volume-title":"Management of Non\u2010Neurogenic Female Lower Urinary Tract Symptoms (LUTS)","author":"Harding C. K.","year":"2025"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17195"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16273"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.03.038"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2024.11.021"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-022-05091-y"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23220"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.05.054"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-023-05655-6"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25244"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-025-06091-4"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2024.10.042"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew466"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23084"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2020.1813098"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2018.1436538"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2017.07.007"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-021-03474-z"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-022-05103-x"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.70080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.70080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.70080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:46:52Z","timestamp":1790552812000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.70080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,12]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/1471-0528.70080"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.70080","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.174685361.17801667\/v1","asserted-by":"object"}]},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,12]]},"assertion":[{"value":"2025-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}