{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:07:15Z","timestamp":1789643235744,"version":"4.0.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008094","name":"The Women's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024715","name":"Australia New Zealand Gynaecological Oncology Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024715","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001773","name":"University of New South Wales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004224","name":"Peter MacCallum Cancer Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012775","name":"Royal Melbourne Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001794","name":"University of Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the effect of surgical menopause (risk\u2010reducing salpingo\u2010oophorectomy, RRSO) on sexual function and the modifying effects of HRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective observational study of women undergoing RRSO and age\u2010matched comparison group who retained their ovaries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>High\u2010risk clinics and general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sexual function was measured at baseline, 3, 6, 12 and 24\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Primary outcome was sexual function at 24\u2009months using the Female Sexual Function Index (FSFI). Secondary outcomes included the Fallowfield Sexual Activity Questionnaire (SAQ) and Female Sexual Distress Scale\u2010Revised (FSDS\u2010R).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline sexual function was similar between groups. At 24\u2009months, sexual dysfunction increased from 19% to 42% after RRSO versus 24% to 29% in comparisons (Odds Ratio (OR) 1.9, 95% CI 0.7\u20135.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.21). Compared to comparisons, sexual desire (\u22120.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), arousal (\u22120.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), lubrication (\u22120.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and satisfaction (\u22120.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were significantly reduced in the RRSO group. Sexual pain (\u22120.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) and discomfort (\u22121.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) increased after RRSO; sexual habit was unchanged. Sexual distress nearly quadrupled in the RRSO group (OR 3.7, 95% CI 1.6\u20139.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). After RRSO, 61% commenced HRT. HRT was not associated with sexual function, activity or distress.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sexual dysfunction and distress increased after RRSO. Use of HRT was not associated with better sexual function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.70158","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:08:55Z","timestamp":1769148535000},"page":"1188-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sexual Function, Activity and Distress 24\u2009Months After Surgical Menopause: What Happens After Menopause (\n                    <scp>WHAM<\/scp>\n                    )\u2014A Prospective Controlled Study"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-082X","authenticated-orcid":false,"given":"Martha","family":"Hickey","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynaecology and Newborn Health University of Melbourne and the Royal Women's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Tejada\u2010Berges","sequence":"additional","affiliation":[{"name":"Gynaecological Oncology Service, Chris O'Brien Lifehouse  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5914-7272","authenticated-orcid":false,"given":"Susan M.","family":"Domchek","sequence":"additional","affiliation":[{"name":"Basser Center for BRCA University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrosinia O.","family":"Krejany","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynaecology and Newborn Health, the Royal Women's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7975-6326","authenticated-orcid":false,"given":"Alison","family":"Brand","sequence":"additional","affiliation":[{"name":"University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Gynaecological Oncology Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0782-2341","authenticated-orcid":false,"given":"Peixuan","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"Methods and Implementation Support for Clinical Health (MISCH) Research Hub, Faculty of Medicine, Dentistry and Health Sciences The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1997-3999","authenticated-orcid":false,"given":"Sabine","family":"Braat","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"Methods and Implementation Support for Clinical Health (MISCH) Research Hub, Faculty of Medicine, Dentistry and Health Sciences The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl","family":"Kingsberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospitals Cleveland Medical Center Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_2_14_2_1","article-title":"Risk\u2010Reducing Bilateral Salpingo\u2010Oophorectomy in Women With BRCA1 or BRCA2 Mutations","volume":"8","author":"Eleje G. 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