{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:14:38Z","timestamp":1782105278716,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To investigate if second trimester pregnancy loss (second trimester miscarriage [STM] or termination for medical reasons [TFMR]) was associated with subsequent adverse pregnancy outcomes.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Conducted using the Aberdeen Maternity and Neonatal Databank [AMND] in Aberdeen, United Kingdom.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n Women with and without a history of STM or TFMR (between 13\u2009+\u20090 and 23\u2009+\u20096\u2009weeks' gestation).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Logistic and linear regression were used to determine associations between exposed (prior STM or TFMR) and unexposed women (women with prior livebirth).<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n The primary outcome was subsequent spontaneous preterm birth, defined as spontaneous onset of labour and birth between 24\u2009+\u20090 and 36\u2009+\u20096\u2009weeks' gestation.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The study included 65\u2009592 women with first and second pregnancies recorded from 1950 to 2017. Women who had a STM in their first pregnancy (\n n<\/jats:italic>\n \u2009=\u2009935) were at significantly greater risk of spontaneous preterm birth in the next pregnancy (4.3% vs. 1.5%; adjusted Odds Ratio [aOR] 2.55 (95% CI 1.81 to 3.50);\n p<\/jats:italic>\n \u2009<\u20090.01). Women with STM in their first pregnancy were two\u2010fold more likely to have a repeat second trimester miscarriage (3.7% vs. 1.1%; aOR 2.25 (95% CI 1.53 to 3.19);\n p<\/jats:italic>\n \u2009<\u20090.01). Women who had a first TFMR (\n n<\/jats:italic>\n \u2009=\u2009177) were significantly more likely to have a repeat TFMR (adjusted OR [aOR] 6.59 (3.4% vs. 0.3%, 95% CI 2.54 to 13.99);\n p<\/jats:italic>\n \u2009<\u20090.01). There was no observed increased risk of spontaneous preterm birth after TFMR detected in this sample (aOR 1.06 (95% CI 0.39 to 2.87);\n p<\/jats:italic>\n \u2009=\u20090.91) though the sample size was too small to be conclusive.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Women with a history of second trimester pregnancy loss have an increased risk of adverse pregnancy outcomes in a subsequent pregnancy. Consequently, antenatal care surveillance and counselling may need to be increased for women with a prior STM, who are at risk of spontaneous preterm birth and other adverse obstetric outcomes including pre\u2010eclampsia. Women after TFMR can be reassured by our findings; however, larger cohorts are needed to confirm these results.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.70161","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T06:51:38Z","timestamp":1769410298000},"page":"1200-1212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pregnancy Outcomes After Second Trimester Pregnancy Loss and Termination for Medical Reasons Before 24\u2009Weeks: A Historical Cohort Study [\n PASTeL<\/scp>\n \u20102]"],"prefix":"10.1111","volume":"133","author":[{"given":"Andrea M. F.","family":"Woolner","sequence":"first","affiliation":[{"name":"School of Medicine, Institute of Applied Health Sciences, Medical Sciences and Nutrition, Aberdeen Centre for Women's Health Research, University of Aberdeen Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Shestopaloff","sequence":"additional","affiliation":[{"name":"Institute of Applied Health Sciences, University of Aberdeen Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-7845","authenticated-orcid":false,"given":"Alexander E. P.","family":"Heazell","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health School of Medical Science, Tommy's Maternal and Fetal Health Research Centre, University of Manchester Manchester UK"},{"name":"Saint Mary's Hospital, Manchester University NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5138"},{"issue":"1","key":"e_1_2_12_3_1","first-page":"240","article-title":"Age\u2010Specific Risk of Fetal Loss Observed in a Second Trimester Serum Screening Population","volume":"192","author":"Wyatt P. 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