{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:12:26Z","timestamp":1787987546190,"version":"build-2784847793"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["PPRCPJT\\100009"],"award-info":[{"award-number":["PPRCPJT\\100009"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015652","name":"Barts Charity","doi-asserted-by":"publisher","award":["G\u2010002207"],"award-info":[{"award-number":["G\u2010002207"]}],"id":[{"id":"10.13039\/100015652","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the analytical suitability of different storage and laboratory processes of self\u2010samples for an HPV assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective matched study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Royal London Hospital Colposcopy Clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>One hundred seventy seven patients aged 25\u201365\u2009years referred to colposcopy due to their screening results (abnormal cytology or recurrent HPV infection).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Each participant provided a first void urine sample (10\u2009mL\/20\u2009mL, Collipee), two vaginal self\u2010samples (Copan FLOQSwabs transported \u2018dry\u2019 and \u2018wet\u2019), and a clinician\u2010collected cervical sample. Samples were processed immediately or after 1 or 2\u2009weeks stored at room temperature. HPV testing used BD Onclarity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Genomic DNA Quality Score (GQS), detection of HPV, and HPV cycle threshold (Ct) values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DNA quality of dry samples was not significantly lower than wet samples when resuspended within 2\u2009weeks (median GQS dry vs. wet: 3.35 vs. 3.41, immediately; 3.00 vs. 3.14, 1\u2009week; 3.45 vs. 2.78, 2\u2009weeks; all\n                      <jats:italic>p<\/jats:italic>\n                      [one\u2010sided]\u2009&gt;\u20090.05). Urine samples had lower HPV positivity compared to other sample types and had higher HPV Ct values (median 30 vs. 27 for dry\/wet\/clinician samples).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dry self\u2010samples from a Copan FLOQSwab taken in clinic are likely to have sufficient DNA quality and accuracy for HPV testing compared with wet self\u2010samples and clinician\u2010collected samples if resuspension takes place up to 2\u2009weeks, with storage at room temperature, and using the BD Onclarity assay. Urine samples using the Colli\u2010pee device are likely to be less sensitive for HPV detected from clinician\u2010collected samples.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.70170","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:20:33Z","timestamp":1770265233000},"page":"1262-1270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the Quality and Suitability of Self\u2010Collected Vaginal and Urine Samples for Human Papillomavirus Testing: A Prospective Matched Study"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0692-1451","authenticated-orcid":false,"given":"Kim","family":"Chu","sequence":"first","affiliation":[{"name":"Barts CTU, Wolfson Institute of Population Health Queen Mary University of London  London 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