{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:54:50Z","timestamp":1770681290807,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Assess uptake of the Core Outcomes in Menopause (COMMA) core outcome sets (COS) and examine whether frontline treatments for vasomotor and genitourinary symptoms have been evaluated against these key outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Methodological review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Published literature and international clinical trial registries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population or Sample<\/jats:title>\n                    <jats:p>Randomised controlled trials evaluating treatments for vasomotor symptoms or genitourinary symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We explored COS uptake in three ways. First, we reviewed outcome reporting in historical randomised trials. Second, we examined recently registered trials to see whether the COS are being adopted. Finally, we consider how frontline treatments\u2014menopause hormone therapy (MHT) for VMS and vaginal oestrogen for genitourinary symptoms\u2014have been evaluated against these COS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Proportion of trial outcomes aligned with the COMMA COS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, alignment of outcome reporting against the COS was moderate and has increased after publication of the COS. While reporting of the distress, bother or interference caused by these symptoms has historically been rare (2% of trials), 62% of registered clinical trials capture this outcome. Common treatments for VMS and genitourinary symptoms, MHT and vaginal oestrogen, have not been evaluated for all core outcomes, with treatment satisfaction and dysuria reported in only 9% of studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite strong endorsement and improvement in capture of symptom experience and impact, uptake of the full COMMA COS is limited. We call on the menopause research community to prioritise reporting of these outcomes that reflect people's lived experience, so that future evidence is more meaningful, comparable and patient\u2010centred.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.70175","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T07:33:38Z","timestamp":1770622418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modern Management of the Menopause: Are We Measuring What Matters?"],"prefix":"10.1111","author":[{"given":"Joscelyn","family":"Gan","sequence":"first","affiliation":[{"name":"Melbourne Medical School University of Melbourne  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Steeper","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynaecology and Newborn Health University of Melbourne  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Hillard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University Hospitals Dorset NHS Trust  Poole Dorset UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Christmas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Shifren","sequence":"additional","affiliation":[{"name":"Midlife Women's Health Center, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Panay","sequence":"additional","affiliation":[{"name":"Queen Charlotte's and Chelsea Hospital Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-082X","authenticated-orcid":false,"given":"Martha","family":"Hickey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynaecology and Newborn Health University of Melbourne  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1694-1142","authenticated-orcid":false,"given":"Sarah","family":"Lensen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynaecology and Newborn Health University of Melbourne  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.24140"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2008.12.006"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2022.09.006"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001570"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15990"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001787"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001788"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000002370"},{"issue":"7","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/GME.0000000000002369","article-title":"Recommended Measurement Instruments for Genitourinary Symptoms Associated With Menopause: The COMMA (Core Outcomes in Menopause) Consortium","volume":"31","author":"Paramanandam V. 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