{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:02:20Z","timestamp":1790694140184,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the diagnostic yield of a nationally implemented first\u2010trimester anomaly scan (FTAS), compared to standard obstetric care with a second\u2010trimester anomaly scan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective observational cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Nationwide prenatal screening program in the Netherlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Pregnant women referred for suspected fetal anomalies with subsequent abnormal diagnostic scans in 2021\u20132022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All fetal diagnoses &lt;\u200918\u2009weeks' gestational age (GA) were registered: 8\u2009months before (BEFORE) and 1\u2009year after (AFTER) FTAS implementation. BEFORE\u2010cohort: referrals after routine scans (e.g., dating scans). AFTER\u2010cohort: all referrals, including FTAS. Corrections were made for missing referrals &lt;\u200912\u2009+\u20093\u2009weeks in the AFTER\u2010cohort. Time adjustment was made in the BEFORE\u2010cohort. Anomalies were categorised as: First\u2010Trimester Major Anomalies (FTMA), often detectable anomalies and other anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Number of fetal anomalies, time to final diagnosis, GA at termination of pregnancy (TOP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Abnormal diagnostic scans increased from 750 to 1261 (BEFORE vs. AFTER) with definitive diagnoses in 609 vs. 940. Time to diagnosis and GA at TOP in c\u2010BEFORE were comparable to c\u2010AFTER (11 vs. 13\u2009days and GA 14\u2009+\u20096 vs. 15\u2009+\u20091, respectively). FTAS increased the detection of often detectable and other anomalies (53 vs. 124 and 248 vs. 474, respectively). FTMA slightly increased (308 vs. 342).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FTAS substantially increases detection of fetal anomalies, primarily often detectable and other anomalies. Overall GA at diagnosis or TOP increased marginally, but some cases required an extended period of diagnostic evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.70192","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:22:46Z","timestamp":1773138166000},"page":"1373-1380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dedicated First\u2010Trimester Anomaly Scan in a National Prenatal Screening Program and Timing of Diagnosis: The Prospective\n                    <scp>IMITAS<\/scp>\n                    Cohort Study"],"prefix":"10.1111","volume":"133","author":[{"given":"Kim","family":"Bronsgeest","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline E. R.","family":"Lust","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University Medical Centre Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3531-0597","authenticated-orcid":false,"given":"Lidewij","family":"Henneman","sequence":"additional","affiliation":[{"name":"Department of Human Genetics and Amsterdam Reproduction and Development Research Institute, Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeltje","family":"Crombag","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University Medical Centre Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina M.","family":"Bilardo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert\u2010Jan H.","family":"Galjaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Erasmus University Medical Centre  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Sikkel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Radboud University Medical Centre  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"van Geloven","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Sciences Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey B. C.","family":"Coumans","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Maastricht UMC+, GROW\u2014Research Institute for Oncology and Reproduction  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayten","family":"Elvan\u2010Ta\u015fp\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University Medical Centre Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Galjaard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Erasmus University Medical Centre  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attie T. J. I.","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Erasmus University Medical Centre  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2463-9127","authenticated-orcid":false,"given":"Elisabeth","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolyn T. R.","family":"Manten","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Isala  Zwolle the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7372-4291","authenticated-orcid":false,"given":"Mireille N.","family":"Bekker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University Medical Centre Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0443-1997","authenticated-orcid":false,"given":"Monique C.","family":"Haak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the IMITAS study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17246"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6389"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6224"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02622.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4802"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1127"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2009.098"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1311"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-1114-6"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/01674820802621775"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14288"},{"key":"e_1_2_12_13_1","article-title":"Introduction of a Nationwide First\u2010Trimester Anomaly Scan in the Dutch National Screening Program","volume":"232","author":"Lust E. 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