{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:00:34Z","timestamp":1781154034631,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To examine the contribution of fetal growth restriction ultrasound phenotypes to adverse perinatal outcomes at term.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective population\u2010based cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n John Radcliffe Hospital, Oxford, UK where universal ultrasound at 35\n +1<\/jats:sup>\n \u201336\n +6<\/jats:sup>\n weeks is performed.\n <\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n \n Congenital abnormalities and births before the scan were excluded. Singleton foetuses were categorised as five mutually exclusive phenotypes using a hierarchical approach:\n \n \n ISUOG fetal growth restriction (FGR), according to Delphi criteria;<\/jats:p>\n <\/jats:list-item>\n \n Constitutional small\u2010for\u2010gestational\u2010age (SGA) (estimated fetal weight [EFW] < 10th centile);<\/jats:p>\n <\/jats:list-item>\n \n Appropriate\u2010for\u2010gestational\u2010age (AGA) with either cerebroplacental ratio\u2009<\u20095th centile or umbilical artery >95th centile;<\/jats:p>\n <\/jats:list-item>\n \n AGA with slowing abdominal circumference growth velocity (ACGV < 10th centile);<\/jats:p>\n <\/jats:list-item>\n \n Normal AGA;<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Univariate logistic regression was employed using normal AGA as the reference group to estimate odds ratio with 95% confidence intervals. Group differences for continuous variables were assessed using mean differences with confidence intervals through a generalised linear model.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n Stillbirth (SB); composite adverse outcome (CAO) (1+ of Grade 2\u20133 encephalopathy, cooling, ventilation >\u200924\u2009h, or perinatal death); severe SGA at birth; neonatal unit admission; obstetric interventions.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 45\u2009179 pregnancies, 54 SBs (0.1%) and 253 CAOs (0.6%) occurred. Normal AGA foetuses at the 35\n +1<\/jats:sup>\n \u201336\n +6<\/jats:sup>\n week scan accounted for 82% of all pregnancies and for 43 (79.6%) SBs and 205 (81%) with the CAO, yet only 37.3% of neonates born with severe SGA. The absolute risk of SB and CAO was similar in all groups (0.1%\u20130.2%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Term FGR and \u2018normal\u2019 babies have similar perinatal risks, presumably because of intervention. Despite a detection rate of 62.7% for severe SGA, most adverse outcomes occurred in pregnancies with a normal scan.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.70207","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:10:33Z","timestamp":1773022233000},"page":"1592-1601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fetal Growth Restriction at a Universal Late Third\u2010Trimester Scan and Relationship With Adverse Outcome: Retrospective Cohort Study"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0526-6329","authenticated-orcid":false,"given":"Elena","family":"D'Alberti","sequence":"first","affiliation":[{"name":"Nuffield Department of Women's & Reproductive Health University of Oxford, University of Oxford Oxford UK"},{"name":"Department of Maternal and Child Health and Urological Sciences Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Granieri","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women's & Reproductive Health University of Oxford, University of Oxford Oxford UK"},{"name":"Department of Obstetrics and Gynecology Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Ioannou","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women's & Reproductive Health University of Oxford, University of Oxford Oxford UK"},{"name":"Women's Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina Y.","family":"Aye","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women's & Reproductive Health University of Oxford, University of Oxford Oxford UK"},{"name":"Women's Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Shea","sequence":"additional","affiliation":[{"name":"Women's Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4462-112X","authenticated-orcid":false,"given":"Lawrence","family":"Impey","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women's & Reproductive Health University of Oxford, University of Oxford Oxford UK"},{"name":"Women's Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22134"},{"key":"e_1_2_12_3_1","unstructured":"NHS England \u201cSaving Babies' Lives: Version 3 A Care Bundle for Reducing Perinatal Mortality \u201d(2023) https:\/\/www.england.nhs.uk\/long\u2010read\/saving\u2010babies\u2010lives\u2010version\u20103\/."},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2024.101294"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.17814"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.29130"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0285096"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14732"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26248"},{"key":"e_1_2_12_10_1","unstructured":"Antenatal Care \u201cNICE Guideline. 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