{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:58:55Z","timestamp":1785463135857,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Long\u2010term child outcomes after intra\u2010uterine exposure to 17\u2010alpha\u2010hydroxyprogesterone caproate (17\u2010OHPC) versus placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Follow\u2010up of the AMPHIA randomised controlled trial assessing neonatal outcomes after weekly 17\u2010OHPC injections compared to placebo in multiple pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Multicentre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population or Sample<\/jats:title>\n                    <jats:p>Children born in the AMPHIA study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children were assessed at 11\u201314\u2009years of age by record linkage and through self\u2010reported, parental and teacher questionnaires. Mean differences or odds ratios (OR) with 95% confidence intervals (95% CI) were calculated with cluster robust standard errors for twins and adjustment for confounders using inverse probability weighting (IPW).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Child mortality, educational attainment, cognition, behaviour, gender identity, general health, and a composite of abnormal development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Up to 14\u2009years, 60\/1356 children had died (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924 17\u2010OHPC and\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936 placebo (OR 0.75 95% CI 0.36\u20131.53)). Record linkage was completed for 1027\/1296 (79%) surviving children (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009517 17\u2010OHPC and\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009510 placebo). No significant difference was found regarding educational attainment. Detailed developmental outcomes through questionnaires were collected for 303\/1296 (23%) surviving children (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009159 17\u2010OHPC and\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009144 placebo). No differences in cognition, behaviour, gender identity, and general health up to 14\u2009years of age were found between both groups. The composite of abnormal development did not differ between 17\u2010OHPC (23.3%) and placebo (20.1%) groups (OR 1.31 95% CI 0.66\u20132.56).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In offspring of women with a multiple pregnancy, the use of 17\u2010OHPC in pregnancy is unlikely to provide positive or negative effects on child outcome related to mortality, educational attainment, cognition and behaviour.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.70223","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:26:36Z","timestamp":1774326396000},"page":"1742-1752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal 17\u2010Alpha\u2010Hydroxyprogesterone Caproate Exposure in Twins and Childhood Outcomes: 14\u2010Year Follow\u2010Up of a Randomised Trial"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2381-0332","authenticated-orcid":false,"given":"Emilie V. J.","family":"van Limburg Stirum","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC Location University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjon A.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"},{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3447-8286","authenticated-orcid":false,"given":"A. C. J.","family":"Ravelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC Location University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"van Eekelen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Amsterdam UMC Location VUmc  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleid G.","family":"Leemhuis","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Paediatrics Emma Children's Hospital, Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn J. J.","family":"Finken","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelieke S. H.","family":"Aarnoudse\u2010Moens","sequence":"additional","affiliation":[{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"},{"name":"Department of Neonatology and Paediatrics Emma Children's Hospital, Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam UMC Location University of Amsterdam, Emma Children's Hospital, Child and Adolescent Psychiatry and Psychosocial Care  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneloes L.","family":"van Baar","sequence":"additional","affiliation":[{"name":"Child and Adolescent Studies Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9109-0800","authenticated-orcid":false,"given":"Noor E.","family":"Simons","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC Location University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Painter","sequence":"additional","affiliation":[{"name":"Amsterdam Reproduction and Development  Amsterdam the Netherlands"},{"name":"Department of Obstetrics and Gynaecology Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam the Netherlands"},{"name":"Department of Obstetrics and Gynaecology Sophia Women's and Children's Hospital, Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianne C.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, GROW School of Oncology and Developmental Biology Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben 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