{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:58:56Z","timestamp":1785463136262,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018234","name":"Inselspital, Universit\u00e4tsspital Bern","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018234","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether angiogenic biomarkers at term in low\u2010risk pregnancies are associated with the timing of spontaneous and induced labour, and to assess changes from term to post\u2010term gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective, non\u2010interventional, observational cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single tertiary care centre, Switzerland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Low\u2010risk term and post\u2010term pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) and placental growth factor (PlGF) were measured and time intervals from sampling to delivery were analysed in spontaneous (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009136) and induced labour (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200948).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Time to spontaneous labour onset and delivery; induction\u2010to\u2010delivery intervals; biomarker changes from term to post\u2010term.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In spontaneous labour, higher sFlt\u20101 levels and sFlt\u20101\/PlGF ratios were inversely correlated with time to delivery (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). The sFlt\u20101\/PlGF ratio remained independently associated with shorter time to delivery after adjustment for gestational age, maternal body mass index, and parity. In induced labour, higher PlGF levels were associated with longer induction\u2010to\u2010delivery intervals (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). From term to post\u2010term, PlGF declined (median 208 vs. 148\u2009pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), whereas sFlt\u20101 (median 3128 vs. 3631\u2009pg\/mL) and the sFlt\u20101\/PlGF ratio (14 vs. 24) increased (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In low\u2010risk term pregnancies, an anti\u2010angiogenic profile is associated with shorter time to spontaneous delivery and increases from term to post\u2010term consistent with physiological placental maturation. In induced labour, biomarkers reflect placental state but do not independently predict induction dynamics. Their potential role in late\u2010term risk assessment warrants further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.70231","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:49:43Z","timestamp":1774658983000},"page":"1777-1784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Angiogenic Serum Biomarker Levels Are Related to Onset of Labour in Low\u2010Risk Term and Post\u2010Term Pregnancies: A Prospective Observational Cohort Study"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5742-8943","authenticated-orcid":false,"given":"Ann\u2010Katrin","family":"Morr","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Inselspital Bern University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4696-5700","authenticated-orcid":false,"given":"Marc","family":"Baumann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Inselspital Bern University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3957-3810","authenticated-orcid":false,"given":"Luigi","family":"Raio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Inselspital Bern University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7705-1584","authenticated-orcid":false,"given":"Daniel","family":"Surbek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Inselspital Bern University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0113-2761","authenticated-orcid":false,"given":"Anda\u2010Petronela","family":"Radan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Inselspital Bern University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31825bd286"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100037\u20101607042"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002838"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0285096"},{"key":"e_1_2_13_6_1","unstructured":"German Society of Gynecology and Obstetrics \u201cInduction of Labor. 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