{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:04:54Z","timestamp":1789790694752,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n Evaluate whether proteinuria levels, in women undergoing expectant management for pre\u2010eclampsia, are associated with pregnancy latency and adverse outcomes.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Secondary analysis of data from two randomised trials.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Tygerberg Hospital, Cape Town, South Africa.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n Women undergoing expectant management for pre\u2010eclampsia diagnosed between 26 and 32\u2009weeks.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Latency was analysed using parametric time\u2010to\u2010event methods to estimate increases. Composite outcomes were assessed using Poisson regression.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n Pregnancy latency Composite adverse maternal or perinatal outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Two hundred and ninety\u2010one women were included. Women with <\u20093\u2009g\/24\u2009h had a median prolongation of 15.3\u2009days (interquartile range (IQR) 4.3 to 25.6), compared to 10.0\u2009days (IQR 5.0 to 19.6) with proteinuria between 3 to 5\u2009g\/24\u2009h; and 4.9\u2009days (IQR 3.8 to 11.7) for those with \u2265\u20095\u2009g\/24\u2009h. Increasing levels were also associated with increases in subsequent adverse composite maternal outcomes: 8.8% of women with <\u20093\u2009g\/24\u2009h experienced maternal complications, compared to 16.1% with 3 to 5\u2009g\/24\u2009h, and 27.9% with \u2265\u20095\u2009g\/24\u2009h. There was no association with composite perinatal adverse outcomes. The sFlt\u20101\/PIGF ratio performed slightly better in predicting latency (area under the receiver operating characteristic curve (AUC) 0.78 vs. 0.67) but similarly in predicting adverse composite maternal outcomes (AUC 0.67 vs. 0.64). Both had poor performance for predicting composite adverse perinatal outcomes (AUC 0.61 vs. 0.56).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Levels of proteinuria strongly correlate with pregnancy latency and adverse maternal outcomes, but not perinatal outcomes, in women with pre\u2010eclampsia undergoing expectant management. They perform similarly to angiogenic markers. Proteinuria levels may confer useful prognostic information to assist clinical decision\u2010making.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.70335","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:26:58Z","timestamp":1789788418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Proteinuria and Pregnancy Outcomes in Women With Preterm Pre\u2010Eclampsia Undergoing Expectant Management: Secondary Analysis of Two Randomised Trials"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5231-6942","authenticated-orcid":false,"given":"Amy van","family":"Rooyen","sequence":"first","affiliation":[{"name":"SAMRC Preeclampsia Extramural Research Unit, Department of Obstetrics and Gynaecology Stellenbosch University Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5202-9428","authenticated-orcid":false,"given":"Lina","family":"Bergman","sequence":"additional","affiliation":[{"name":"SAMRC Preeclampsia Extramural Research Unit, Department of Obstetrics and Gynaecology Stellenbosch University Cape Town South Africa"},{"name":"Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9447-663X","authenticated-orcid":false,"given":"Henrik","family":"Imberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Statistiska Konsultgruppen Sweden AB Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2138-0495","authenticated-orcid":false,"given":"Denise","family":"Sproul","sequence":"additional","affiliation":[{"name":"SAMRC Preeclampsia Extramural Research Unit, Department of Obstetrics and Gynaecology Stellenbosch University Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9075-4655","authenticated-orcid":false,"given":"Susan P.","family":"Walker","sequence":"additional","affiliation":[{"name":"Translational Obstetrics Group, Department of Obstetrics, Gynaecology and Newborn Health University of Melbourne Victoria Australia"},{"name":"Mercy Perinatal Mercy Hospital for Women Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2319-0586","authenticated-orcid":false,"given":"Stephen","family":"Tong","sequence":"additional","affiliation":[{"name":"Translational Obstetrics Group, Department of Obstetrics, Gynaecology and Newborn Health University of Melbourne Victoria Australia"},{"name":"Mercy Perinatal Mercy Hospital for Women Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0406-8964","authenticated-orcid":false,"given":"Catherine A.","family":"Cluver","sequence":"additional","affiliation":[{"name":"SAMRC Preeclampsia Extramural Research Unit, Department of Obstetrics and Gynaecology Stellenbosch University Cape Town South Africa"},{"name":"Mercy Perinatal Mercy Hospital for Women Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","first-page":"67","article-title":"ACOG Practice Bulletin. 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