{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:32:04Z","timestamp":1782826324568,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development Service","award":["SDP\u00a010-044"],"award-info":[{"award-number":["SDP\u00a010-044"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Services Research"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To test the effectiveness of a collaborative depression care model in improving depression and hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources\/Study Setting<\/jats:title><jats:p>Hepatitis C virus clinic patients who screened positive for depression at four Veterans Affairs Hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>We compared off\u2010site depression collaborative care (delivered by depression care manager, pharmacist, and psychiatrist) with usual care in a randomized trial. Primary depression outcomes were treatment response (\u226550 percent decrease in 20\u2010item Hopkins Symptoms Checklist [<jats:styled-content style=\"fixed-case\">SCL<\/jats:styled-content>\u201020] score), remission (mean <jats:styled-content style=\"fixed-case\">SCL<\/jats:styled-content>\u201020 score, &lt;0.5), and depression\u2010free days (<jats:styled-content style=\"fixed-case\">DFD<\/jats:styled-content>s). Primary <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> outcome was receipt of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Collection<\/jats:title><jats:p>Patient data were collected by self\u2010report telephone surveys at baseline and 12\u00a0months, and from electronic medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Principal Findings<\/jats:title><jats:p>Baseline screening identified 292 <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected patients with depression, and 242 patients completed 12\u2010month follow\u2010up (82.9 percent). Intervention participants were more likely to report depression treatment response, remission, and more <jats:styled-content style=\"fixed-case\">DFD<\/jats:styled-content>s than usual care participants. Intervention participants were more likely to receive antiviral treatment; however, the difference was not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Off\u2010site depression collaborative care improved depression outcomes in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> patients and may serve as a model for collaboration between mental health and specialty physical health providers in other high co\u2010occurring conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1475-6773.12758","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T06:06:38Z","timestamp":1505109998000},"page":"2547-2566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Randomized Trial of Off\u2010Site Collaborative Care for Depression in Chronic Hepatitis C Virus"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1012-8767","authenticated-orcid":false,"given":"Fasiha","family":"Kanwal","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Baylor College of Medicine Center for Innovations in Quality, Effectiveness and Safety (IQuESt) Michael E. 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DeBakey Veterans Affairs Medical Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Nicholson","sequence":"additional","affiliation":[{"name":"John Cochran VA Medical Center Gastroenterology Section\u00a0(111\/JC\/GI) St. Louis MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Dieckgraefe","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine John Cochran Veterans Affairs Medical Center Gastroenterology Section\u00a0(111\/JC\/GI) St. Louis MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erma","family":"Storay","sequence":"additional","affiliation":[{"name":"Central Arkansas Veterans Healthcare System Little Rock AR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew Bidwell","family":"Goetz","sequence":"additional","affiliation":[{"name":"Infectious Diseases VA Greater Los Angeles Healthcare System Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Medicine Baylor College of Medicine Center for Innovations in Quality, Effectiveness and Safety (IQuESt) Michael E. 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