{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:38:32Z","timestamp":1777477112526,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["R01\u2010HS\u2010024914"],"award-info":[{"award-number":["R01\u2010HS\u2010024914"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Services Research"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the feasibility of soliciting outcomes from adults who received chemotherapy treatment for cancer and describe the patterns and correlates of patient\u2010reported toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Patient survey data from 29 Michigan ambulatory oncology practices collected in 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Secondary analysis of patient survey data. Descriptive statistics were generated at the patient and practice levels. Thematic analysis of open\u2010text comments identified clusters of frequently reported toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Collection Methods<\/jats:title><jats:p>Patients completed 11 items from the Patient\u2010Reported Outcomes version of the Common Terminology Criteria for Adverse Events. Using a 5\u2010point Likert scale, patients rated the frequency of nausea, vomiting, diarrhea, and pain; the severity of nausea, vomiting, constipation, numbness\/tingling, and pain; and how much numbness\/tingling and pain interfered with usual or daily activities. Patients could also report two toxicities in open\u2010text comments. Finally, patients reported unplanned health care service for toxicity or side effect management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Principal Findings<\/jats:title><jats:p>Of 3565 eligible patients, 2245 participated (63%) and 457 (20%) rated at least one toxicity as severe\/very severe. Across practices, the proportion of patients who reported at least one severe\/very severe toxicity ranged from 8% to 50%. Troubling toxicities included pain frequency (mean 2.3, SD 1.3), pain severity (2.1, 1.1), and diarrhea frequency (1.9, 1.0). From completed assessments, 1653 (74%) reported at least one toxicity in open\u2010text comments; fatigue (<jats:italic>n<\/jats:italic>\u00a0=\u00a0182), stomach discomfort (<jats:italic>n<\/jats:italic>\u00a0=\u00a053), and skin\/nail changes (<jats:italic>n<\/jats:italic>\u00a0=\u00a041) were most frequently reported. Regarding consequences, 156 patients (7%) reported unplanned health care service use: 41 (26%) visited an emergency department and 32 (21%) were admitted to a hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Querying patients on chemotherapy treatment experiences and toxicities was feasible. Toxicity rates varied across practices, which informed quality improvement. Toxicity severity and service use incidence exceed previously published trial data, particularly for pain, fatigue, and gastrointestinal issues. Open\u2010text questions enabled exploration with newer treatment regimens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1475-6773.13574","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T14:42:20Z","timestamp":1604068940000},"page":"966-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Patient\u2010reported outcomes collected in ambulatory oncology practices: Feasibility, patterns, and correlates"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2281-2056","authenticated-orcid":false,"given":"Christopher R.","family":"Friese","sequence":"first","affiliation":[{"name":"Center for Improving Patient and Population Health School of Nursing Department of Health Management and Policy, School of Public Health University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex J.","family":"Fauer","sequence":"additional","affiliation":[{"name":"National Clinician Scholars Program David Geffen School of Medicine, and Fielding School of Public Health University of California Los Angeles Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Kuisell","sequence":"additional","affiliation":[{"name":"Hillman Scholar in Nursing Innovation School of Nursing University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Mendelsohn\u2010Victor","sequence":"additional","affiliation":[{"name":"Center for Improving Patient and Population Health School of Nursing University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan C.","family":"Wright","sequence":"additional","affiliation":[{"name":"Center for Improving Patient and Population Health School of Nursing University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer J.","family":"Griggs","sequence":"additional","affiliation":[{"name":"Internal Medicine and Health Management and Policy University of Michigan Ann Arbor MI USA"},{"name":"Michigan Oncology Quality Collaborative Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6101-5535","authenticated-orcid":false,"given":"Milisa","family":"Manojlovich","sequence":"additional","affiliation":[{"name":"School of Nursing University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"issue":"6","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1200\/JCO.2015.64.9491","article-title":"PRO\u2010cision Medicine: Personalizing patient care using patient\u2010reported outcomes","volume":"34","author":"Jensen RE","year":"2016","journal-title":"J Clin Oncol"},{"key":"e_1_2_8_3_1","volume-title":"Institute of Medicine, Committee on Quality of Health Care in America; Institute of Medicine. 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