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Abstracts were reviewed iteratively to refine inclusion and exclusion criteria. The search was supplemented by manually searching the bibliographic sections of the included studies. The search included a forward citation search of studies nested within a clinical trial to identify the clinical trial protocol and published clinical trial results. Data were extracted independently by two reviewers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Principal Findings<\/jats:title><jats:p>The search yielded 1907 articles; 44 were included. Nine randomized controlled trials (RCTs) and 35 other studies including quasi\u2010experimental, usability, feasibility, qualitative studies, or development\/validation studies of analytic models were included. Five RCTs had positive results, and the remaining four RCTs showed that the interventions had no effect. The studies address individual patient engagement and assess patient\u2010centered outcomes such as quality of life. Few RCTs assess outcomes such as disability and none assess mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite a growing body of literature on health IT interventions or multicomponent interventions including a health IT component for chronic disease management, current evidence for applying health IT solutions to improve care for PLWMCC is limited. The body of literature included in this review provides critical information on the state of the science as well as the many gaps that need to be filled for digital health to fulfill its promise in supporting care delivery that meets the needs of PLWMCC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1475-6773.13860","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T08:11:48Z","timestamp":1628323908000},"page":"1006-1036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Health information technology to improve care for people with multiple chronic conditions"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6384-4946","authenticated-orcid":false,"given":"Lipika","family":"Samal","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital  Boston MA USA"},{"name":"Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen N.","family":"Fu","sequence":"additional","affiliation":[{"name":"Indiana University Richard M. 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