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Reduced use of potentially inappropriate medications (PIMs) can be addressed by deprescribing\u2014a systematic process of discontinuing and\/or reducing the use of PIMs. The 4Ms\u2014\u201cMedication\u201d, \u201cMentation\u201d, \u201cMobility\u201d, and \u201cWhat Matters Most\u201d to the person\u2014can be used to guide assessment of age\u2010friendliness of deprescribing trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Source<\/jats:title><jats:p>Published literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Scoping review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Extraction Methods<\/jats:title><jats:p>The literature was identified using keywords related to deprescribing and polypharmacy in PubMed, EMBASE, Web of Science, ProQuest, CINAHL, and Cochrane and snowballing. Study characteristics were extracted and evaluated for consideration of 4Ms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Principal Findings<\/jats:title><jats:p>Thirty\u2010seven of the 564 trials identified met the review eligibility criteria. Intervention design: \u201cMedication\u201d was considered in the intervention design of all trials; \u201cMentation\u201d was considered in eight trials; \u201cMobility\u201d (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) and \u201cWhat Matters Most\u201d (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) were less often considered in the design of intervention. Most trials targeted providers without specifying how matters important to older adults and their families were aligned with deprescribing decisions. Outcome assessment: \u201cMedication\u201d was the most commonly assessed outcome (<jats:italic>n<\/jats:italic>\u00a0=\u00a033), followed by \u201cMobility\u201d (<jats:italic>n<\/jats:italic>\u00a0=\u00a013) and \u201cMentation\u201d (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) outcomes, with no study examining \u201cWhat Matters Most\u201d outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>\u201cMentation\u201d and \u201cMobility\u201d, and \u201cWhat Matters Most\u201d have been considered to varying degrees in deprescribing trials, limiting the potential of deprescribing evidence to contribute to improved clinical practice in building an age\u2010friendly health care system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1475-6773.14083","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T03:29:28Z","timestamp":1665545368000},"page":"123-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["How \u201c<scp>age\u2010friendly<\/scp>\u201d are deprescribing interventions? 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