{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:02:40Z","timestamp":1779343360250,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"vor","delay-in-days":6633,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[1997,11]]},"DOI":"10.1111\/1523-1747.ep12337662","type":"journal-article","created":{"date-parts":[[2004,7,13]],"date-time":"2004-07-13T11:43:25Z","timestamp":1089719005000},"page":"650-655","source":"Crossref","is-referenced-by-count":39,"title":["Pemphigus IgG Induces Expression of Urokinase Plasminogen Activator Receptor on the Cell Surface of Cultured Keratinocytes"],"prefix":"10.1016","volume":"109","author":[{"given":"Mariko","family":"Seishima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiho","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Nojiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Osada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Kitajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/1523-1747.ep12337662_bb0010","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/1523-1747.ep12343081","article-title":"Pemphigus vulgaris antigen (desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients","volume":"106","author":"Amagai","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0015","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/(SICI)1097-4652(199606)167:3<500::AID-JCP14>3.0.CO;2-7","article-title":"Protein kinase C mediates up-regulation of urokinase and its receptor in the migrating keratinocytes of wounded cultures, but urokinase is not required for movement across a substratum in vitro","volume":"167","author":"Ando","year":"1996","journal-title":"J Cell Physiol"},{"key":"10.1111\/1523-1747.ep12337662_bb0020","doi-asserted-by":"crossref","first-page":"6453","DOI":"10.1016\/S0021-9258(19)39348-2","article-title":"The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants","volume":"265","author":"Behrendt","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12337662_bb0025","first-page":"269","article-title":"The structure and function of the urokinase receptor, a membrane protein governing plasminogen activation on the cell surface","volume":"376","author":"Behrendt","year":"1995","journal-title":"Biol Chem Hoppe-Scyler"},{"key":"10.1111\/1523-1747.ep12337662_bb0030","doi-asserted-by":"crossref","first-page":"22885","DOI":"10.1074\/jbc.271.37.22885","article-title":"Domain interplay in the urokinase receptor. Requirement for the third domain in high affinity ligand binding and demonstration of ligand contact sites in distinct receptor domains","volume":"271","author":"Behrendt","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12337662_bb0035","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/1523-1747.ep12665844","article-title":"Differential regulation of plasminogen activation in normal keratinocytes and SCC-4 cells by fibroblasts","volume":"104","author":"Boxman","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0040","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2133.1992.tb08400.x","article-title":"Plasminogen binding sites in normal human skin","volume":"126","author":"Burge","year":"1992","journal-title":"Br J Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0045","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1083\/jcb.121.3.481","article-title":"Nomenclature of desmosomal cadherins","volume":"121","author":"Buxton","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1111\/1523-1747.ep12337662_bb0050","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1242\/jcs.106.1.45","article-title":"Differential expression of plasminogen activators and their inhibitors in an organotypic skin coculture system","volume":"106","author":"Chen","year":"1993","journal-title":"J Cell Sci"},{"key":"10.1111\/1523-1747.ep12337662_bb0055","first-page":"143","article-title":"Urokinase\/urokinase receptor system: internalization\/degradation of urokinase-serpin complexes: mechanism and regulation","volume":"376","author":"Conese","year":"1995","journal-title":"Biol Chem Hoppe-Seyler"},{"key":"10.1111\/1523-1747.ep12337662_bb0060","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0014-5793(94)01399-L","article-title":"PMA-induced downregulation of the receptor for \u03b12-macroglobulin in human U937 cells","volume":"358","author":"Conese","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1111\/1523-1747.ep12337662_bb0065","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1600-0625.1993.tb00040.x","article-title":"Calcium-independent increases in pericellular plasminogen activator activity in pemphigus vulgaris","volume":"2","author":"Crameri","year":"1993","journal-title":"Exp Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0070","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0065-230X(08)60028-7","article-title":"Plasminogen activators, tissue degradation, and cancer","volume":"44","author":"Dan\u00f8","year":"1985","journal-title":"Adv Cancer Res"},{"key":"10.1111\/1523-1747.ep12337662_bb0075","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1083\/jcb.134.6.1563","article-title":"Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?","volume":"134","author":"Deng","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1111\/1523-1747.ep12337662_bb0080","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/BF02505273","article-title":"Proteinase inhibitors and pemphigus vulgaris. An in vitro and in vivo study","volume":"288","author":"Dobrev","year":"1996","journal-title":"Arch Dermatol Res"},{"key":"10.1111\/1523-1747.ep12337662_bb0085","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/1523-1747.ep12319948","article-title":"Pharmacologic evidence for involvement of phospholipase C in pemphigus IgG induced inositol 1,4,5-trisphosphate generation, intracellular calcium increase, and plasminogen activator secretion in DJM 1 cells, a squamous cell carcinoma line","volume":"105","author":"Esaki","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0090","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1172\/JCI113387","article-title":"Identification of pemphigus vulgaris antigen extracted from normal human epidermis and comparison with pemphigus foliaceus antigen","volume":"81","author":"Eyre","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1111\/1523-1747.ep12337662_bb0095","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1084\/jem.157.1.259","article-title":"Anti-cell surface pemphigus antibody stimulates plasminogen activator activity of human epidermal cells. A mechanism for the loss of epidermal cohesion and blister formation","volume":"157","author":"Hashimoto","year":"1983","journal-title":"J Exp Med"},{"key":"10.1111\/1523-1747.ep12337662_bb0100","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/1523-1747.ep12277087","article-title":"Characterization of keratinocyte plasminogen activator inhibitors and demonstration of the prevention of pemphigus IgG-induced acantholysis by a purified plasminogen activator inhibitor","volume":"92","author":"Hashimoto","year":"1989","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0105","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/1523-1747.ep12874456","article-title":"Detection of pemphigus vulgaris and pemphigus foliaceus antigens by immunoblot analysis using different antigen sources","volume":"94","author":"Hashimoto","year":"1990","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0110","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000246934","article-title":"Regulation of pemphigus and desmosomal antigen expression by keratinocyte differentiation","volume":"189","author":"Iwatsuki","year":"1994","journal-title":"Dermatology"},{"key":"10.1111\/1523-1747.ep12337662_bb0115","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/1523-1747.ep12461494","article-title":"Epidermal plasminogen activator is abnormal in cutaneus lesions","volume":"90","author":"Jensen","year":"1988","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0120","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1083\/jcb.102.3.1109","article-title":"Further analysis of pemphigus autoantibodies and their use in studies on the heterogeneity, structure and function of desmosomes","volume":"102","author":"Jones","year":"1986","journal-title":"J Cell Biol"},{"key":"10.1111\/1523-1747.ep12337662_bb0125","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1365-2133.1987.tb07347.x","article-title":"A monoclonal antibody recognizing plasminogen and plasmin-altered reactivity in psoriatic lesions","volume":"117","author":"Justus","year":"1987","journal-title":"Br J Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0130","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1083\/jcb.122.2.409","article-title":"Pemphigus vulgaris antigen, a desmoglein type of cadherin, is located within keratinocyte desmosomes","volume":"122","author":"K\u00e1rp\u00e1ti","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1111\/1523-1747.ep12337662_bb0135","first-page":"399","article-title":"Adhesion molecules in the pathophysiology of bullous diseases","volume":"6","author":"Kitajima","year":"1996","journal-title":"Eur J Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0140","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/1523-1747.ep12470554","article-title":"Effects of pemphigus antibody on the regeneration of cell\u2013cell contact in keratinocyte culture in low to normal Ca++ concentration","volume":"89","author":"Kitajima","year":"1987","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0145","first-page":"964","article-title":"Biphasic effects of 12-O-tetradecanoylphorbol-13-acetate on the cell morphology of low calcium-grown human epidermal carcinoma cells: involvement of translocation and down regulation of protein kinase C","volume":"48","author":"Kitajima","year":"1988","journal-title":"Cancer Res"},{"key":"10.1111\/1523-1747.ep12337662_bb0150","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0303-7207(95)03504-Z","article-title":"Differential regulation of urokinase-type-1 inhibitor complex endocytosis by phorbol esters in different cell lines is associated with differential regulation of \u03b12-macroglobulin receptor and urokinase receptor expression","volume":"109","author":"Kj\u00f8ller","year":"1995","journal-title":"Mol Cell Endocrinol"},{"key":"10.1111\/1523-1747.ep12337662_bb0155","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1056\/NEJM198909073211002","article-title":"Demonstration of an adhering junction molecule (plakoglobin) in the autoantigens of pemphigus foliaceus and pemphigus vulgaris","volume":"321","author":"Korman","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1111\/1523-1747.ep12337662_bb0160","first-page":"131","article-title":"Plasminogen activation by human keratinocytes: molecular pathways and cell-biological consequences","volume":"376","author":"Kramer","year":"1995","journal-title":"Biol Chem Hoppe-Seyler"},{"key":"10.1111\/1523-1747.ep12337662_bb0165","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1111\/1523-1747.ep12337662_bb0170","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1021\/bi00518a011","article-title":"A quantitative assay for the activation of plasminogen by transformed cells in situ and by urokinase","volume":"20","author":"Leytus","year":"1981","journal-title":"Biochemistry"},{"key":"10.1111\/1523-1747.ep12337662_bb0175","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1042\/bj3100345","article-title":"Transcriptional and post-transcriptional regulation of the receptor for urokinase-type plasminogen activator by cytokines and tumour promoters in the human lung carcinoma cell line A549","volume":"310","author":"Lund","year":"1995","journal-title":"Biochem J"},{"key":"10.1111\/1523-1747.ep12337662_bb0180","doi-asserted-by":"crossref","first-page":"13691","DOI":"10.1016\/S0021-9258(19)38702-2","article-title":"\u03b12-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the \u03b12-macroglobulin receptor containing a cluster of eight complement-type repeats","volume":"268","author":"Moestrup","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12337662_bb0185","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/S0021-9258(18)82104-4","article-title":"N-linked glycosylation of the ligand-binding domain of the human urokinase receptor contributes to the affinity for its ligand","volume":"268","author":"M\u00f8ller","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12337662_bb0190","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/1523-1747.ep12519988","article-title":"The pathogenic role of pemphigus antibodies and proteitiase in epidermal acantholysis","volume":"76","author":"Morioka","year":"1981","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0195","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1016\/S0021-9258(18)69214-2","article-title":"A, 55,000\u201360,000Mr receptor protein for urokinase-type plasminogen activator. Identification in human tumor cell lines and partial purification","volume":"263","author":"Nielsen","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12337662_bb0200","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/1523-1747.ep12289726","article-title":"Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate\/cytoskeleton fractions in human keratinocytes","volume":"108","author":"Osada","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0205","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1083\/jcb.122.3.673","article-title":"Upregulation of urokinase receptor expression on migration endothelial cells","volume":"122","author":"Pepper","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1111\/1523-1747.ep12337662_bb0210","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/S0021-9258(18)52382-6","article-title":"Cellular receptor for urokinase plasminogen activator Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol","volume":"266","author":"Ploug","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12337662_bb0215","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0065-230X(08)61002-7","article-title":"Directed plasminogen activation at the surface of normal and malignant cells","volume":"57","author":"P\u00f6ll\u00e4nen","year":"1991","journal-title":"Adv Cancer Res"},{"key":"10.1111\/1523-1747.ep12337662_bb0220","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/excr.1993.1238","article-title":"Binding and activation of plasminogen at the surface of human keratinocytes","volume":"208","author":"Reinartz","year":"1993","journal-title":"Exp Cell Res"},{"key":"10.1111\/1523-1747.ep12337662_bb0225","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/BF00373352","article-title":"Plasminogen activation in lesional skin of pemphigus vulgaris type Neumann","volume":"284","author":"Reinartz","year":"1993","journal-title":"Arch Dermatol Res"},{"key":"10.1111\/1523-1747.ep12337662_bb0230","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1006\/excr.1994.1286","article-title":"The receptor for urokinase-type plasminogen activator of a human keratinocyte cell line (HaCaT)","volume":"214","author":"Reinartz","year":"1994","journal-title":"Exp Cell Res"},{"key":"10.1111\/1523-1747.ep12337662_bb0235","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/j.1365-2133.1996.tb03881.x","article-title":"Plasminogen activator system in pemphigus vulgaris","volume":"135","author":"Schaefer","year":"1996","journal-title":"Br J Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0240","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/1523-1747.ep12613469","article-title":"Pemphigus IgG, but not bullous pemphigoid IgG, causes a transient increase in intracellular calcium and inositol 1,4,5-trisphosphate in DJM-1 cells, a squamous cell carcinoma line","volume":"104","author":"Seishima","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12337662_bb0245","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1126\/science.1719635","article-title":"GPI-anchored cell-surface molecules complexed to protein tyrosine kinases","volume":"254","author":"Stefanova","year":"1991","journal-title":"Science"},{"key":"10.1111\/1523-1747.ep12337662_bb0250","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0922-3371(90)90038-X","article-title":"Plasminogen activation at the cell surface\u2013matrix interface","volume":"32","author":"Vaheri","year":"1990","journal-title":"Cell Differ Dev"},{"key":"10.1111\/1523-1747.ep12337662_bb0255","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1172\/JCI115405","article-title":"The plasnunogen activator\/plasmin system","volume":"88","author":"Vassalli","year":"1991","journal-title":"J Clin Invest"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X1543043X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X1543043X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T05:17:58Z","timestamp":1624511878000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X1543043X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["S0022202X1543043X"],"URL":"https:\/\/doi.org\/10.1111\/1523-1747.ep12337662","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}