{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:19:05Z","timestamp":1791058745653,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":7215,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[1996,3]]},"DOI":"10.1111\/1523-1747.ep12344044","type":"journal-article","created":{"date-parts":[[2004,7,12]],"date-time":"2004-07-12T22:57:23Z","timestamp":1089673043000},"page":"564-570","source":"Crossref","is-referenced-by-count":107,"title":["The Insulin-like Growth Factor 1 Receptor Is Expressed by Epithelial Cells with Proliferative Potential in Human Epidermis and Skin Appendages: Correlation of Increased Expression with Epidermal Hyperplasia"],"prefix":"10.1016","volume":"106","author":[{"given":"Emmilia","family":"Hodak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice B.","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Anzilotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Krueger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/1523-1747.ep12344044_bb0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1164\/ajrccm\/142.6_Pt_2.S7","article-title":"Growth factor-regulated pathways in epithelial cell proliferation","volume":"142","author":"Aaronson","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"10.1111\/1523-1747.ep12344044_bb0015","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0065-2423(08)60124-9","article-title":"The somatomedins: insulinlike growth factors","volume":"25","author":"Baxter","year":"1986","journal-title":"Adv Clin Chem"},{"key":"10.1111\/1523-1747.ep12344044_bb0020","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1083\/jcb.107.2.811","article-title":"Focal expression of insulin-like growth factor 1 in rat kidney collecting duct","volume":"107","author":"Bortz","year":"1988","journal-title":"J Cell Biol"},{"key":"10.1111\/1523-1747.ep12344044_bb0025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2184.1992.tb01435.x","article-title":"Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells","volume":"25","author":"Bruno","year":"1992","journal-title":"Cell Prolif"},{"key":"10.1111\/1523-1747.ep12344044_bb0030","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1210\/jcem-62-4-692","article-title":"The human erythrocyte insulin-like growth factor receptor: characterization and demonstration of ligand-stimulated autophosphorylation","volume":"62","author":"Catanese","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1111\/1523-1747.ep12344044_bb0035","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0092-8674(89)90281-X","article-title":"Signal transmission by the insulin-like growth factors","volume":"59","author":"Czech","year":"1989","journal-title":"Cell"},{"key":"10.1111\/1523-1747.ep12344044_bb0040","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1210\/edrv-10-1-68","article-title":"Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations","volume":"10","author":"Daughaday","year":"1989","journal-title":"Endocr Rev"},{"key":"10.1111\/1523-1747.ep12344044_bb0045","series-title":"Dermatology in General Medicine","first-page":"2063","article-title":"Cutaneous manifestation of endocrine disorders","author":"Freinkel","year":"1987"},{"key":"10.1111\/1523-1747.ep12344044_bb0050","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1210\/jcem-64-6-1142","article-title":"The type II insulin-like growth factor receptor does not mediate deoxyribonucleic acid synthesis in human fibroblasts","volume":"64","author":"Furlanetto","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1111\/1523-1747.ep12344044_bb0055","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/1523-1747.ep12276708","article-title":"Differences in human skin between the epidermal growth factor receptor distribution detected by EGF binding and monoclonal antibody recognition","volume":"85","author":"Green","year":"1985","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12344044_bb0060","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/341758a0","article-title":"A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase","volume":"341","author":"Harding","year":"1989","journal-title":"Nature"},{"key":"10.1111\/1523-1747.ep12344044_bb0065","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1172\/JCI115794","article-title":"Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis","volume":"89","author":"Hertle","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1111\/1523-1747.ep12344044_bb0070","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1432-0436.1986.tb00395.x","article-title":"Monoclonal antibodies to various acidic (type I) cytokeratins of stratified epithelia. Selective markers for stratification and squamous cell carcinomas","volume":"31","author":"Huszar","year":"1986","journal-title":"Differentiation"},{"key":"10.1111\/1523-1747.ep12344044_bb0075","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1210\/endo-118-1-223","article-title":"Interaction of the monoclonal antibodies \u03b1-IR-1 and \u03b1-IR-3 with insulin and somatomedin-C receptors","volume":"118","author":"Jacobs","year":"1986","journal-title":"Endocrinology"},{"key":"10.1111\/1523-1747.ep12344044_bb0080","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1084\/jem.175.4.1081","article-title":"The insulin-like growth factor I receptor is overexpresscd in psoriatic epidermis, but is differentially regulated from the epidermal growth factor receptor","volume":"175","author":"Krane","year":"1992","journal-title":"J Exp Med"},{"key":"10.1111\/1523-1747.ep12344044_bb0085","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/1523-1747.ep12469799","article-title":"Synergistic effects of epidermal growth factor (EGF) and insulin-like growth factor 1\/somatomedin C (IGF-1) on keratinocyte proliferation may be mediated by IGF-1 transmodulation of the EGF receptor","volume":"96","author":"Krane","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12344044_bb0090","doi-asserted-by":"crossref","first-page":"6561","DOI":"10.1016\/S0021-9258(18)32449-9","article-title":"Monoclonal antibodies to receptor for insulin and somaiomedin C","volume":"258","author":"Kull","year":"1983","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12344044_bb0095","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1083\/jcb.129.2.357","article-title":"Specific receptor detection by a functional keratinocyte growth factor-immunoglobulin chimera","volume":"129","author":"LaRochelle","year":"1995","journal-title":"J Cell Biol"},{"key":"10.1111\/1523-1747.ep12344044_bb0100","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/1523-1747.ep12471216","article-title":"Changes in keratinocyte maturation during wound healing","volume":"89","author":"Mansbridge","year":"1987","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12344044_bb0105","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1016\/S0021-9258(18)34631-3","article-title":"The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor","volume":"257","author":"Massague","year":"1982","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12344044_bb0110","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/1523-1747.ep12696645","article-title":"Characterization of insulin-like growth factor-1\/somatomedin-C receptors on human keratinocyte monolayers","volume":"87","author":"Misra","year":"1986","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12344044_bb0115","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/1523-1747.ep12264708","article-title":"Comparison of epidermal growth factor binding and receptor distribution in normal human epidermis and epidermal appendages","volume":"83","author":"Nanney","year":"1984","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12344044_bb0120","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000248577","article-title":"Further characterization of the keratinocyte somatomedin-C\/insulin-like growth factor I (SM-C\/IGF-1) receptor and the biological responsiveness of cultured keratinocytes to SM-C\/IGF-1","volume":"177","author":"Nickoloff","year":"1988","journal-title":"Dermatologica (Basel)"},{"key":"10.1111\/1523-1747.ep12344044_bb0125","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/1523-1747.ep12382494","article-title":"Effects of insulin and insulin-like growth factors on cultured human hair follicles. IGF-1 at physiologic concentrations is an important regulator of hair follicle growth in vitro","volume":"102","author":"Philpott","year":"1994","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12344044_bb0130","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2340\/0001555551413422","article-title":"Proliferative cells in the human sebaceous gland. Labelling index and regional variations","volume":"51","author":"Plewig","year":"1971","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"10.1111\/1523-1747.ep12344044_bb0135","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/jcp.1041370210","article-title":"Basic fibroblast growth factor and insulin-like growth factor I are strong mitogens for cultured mouse keratinocytes","volume":"137","author":"Ristow","year":"1988","journal-title":"J Cell Physiol"},{"key":"10.1111\/1523-1747.ep12344044_bb0140","first-page":"269","article-title":"Determinants of rate and kinetics of cell division in scalp hair","volume":"71","author":"Van Scott","year":"1963","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12344044_bb0145","doi-asserted-by":"crossref","first-page":"21172","DOI":"10.1016\/S0021-9258(17)45342-7","article-title":"Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells","volume":"265","author":"Stewart","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12344044_bb0150","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/1523-1747.ep12616668","article-title":"Expression of growth hormone receptor, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor mRNA and proteins in human skin","volume":"99","author":"Tavakkol","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12344044_bb0155","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1002\/j.1460-2075.1986.tb04528.x","article-title":"Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity","volume":"5","author":"Ullrich","year":"1986","journal-title":"EMBO"},{"key":"10.1111\/1523-1747.ep12344044_bb0160","series-title":"Dermatology in General Medicine","first-page":"154","article-title":"Epidermal cell kinetics","author":"Weinstei","year":"1987"},{"key":"10.1111\/1523-1747.ep12344044_bb0165","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/jcp.1041210106","article-title":"Integrated control of growth and differentiation of normal human prokeratinocytes cultured in serum-free medium: clonal analyses, growth kinetics, and cell cycle studies","volume":"121","author":"Wille","year":"1984","journal-title":"J Cell Physiol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15424923?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15424923?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T21:26:16Z","timestamp":1705181176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15424923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["S0022202X15424923"],"URL":"https:\/\/doi.org\/10.1111\/1523-1747.ep12344044","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[1996,3]]}}}