{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T13:45:18Z","timestamp":1751031918612},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1994,2,1]],"date-time":"1994-02-01T00:00:00Z","timestamp":760060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":7974,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[1994,2]]},"DOI":"10.1111\/1523-1747.ep12371754","type":"journal-article","created":{"date-parts":[[2004,7,12]],"date-time":"2004-07-12T14:33:09Z","timestamp":1089642789000},"page":"155-159","source":"Crossref","is-referenced-by-count":10,"title":["Heterogeneity of Severe Dystrophic Epidermolysis Bullosa: Overexpression of Collagen VII by Cutaneous Cells from a Patient with Mutilating Disease"],"prefix":"10.1016","volume":"102","author":[{"given":"Adrian","family":"K\u00f6nig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Olof","family":"Winberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Tobias","family":"Gedde-Dahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Bruckner-Tuderman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/1523-1747.ep12371754_bb0010","first-page":"855","article-title":"Epidermolysis bullosa","volume":"1","author":"Gedde-Dahl","year":"1990"},{"key":"10.1111\/1523-1747.ep12371754_bb0015","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0190-9622(91)70021-S","article-title":"Revised clinical and laboratory criteria for subtypes of inherited epidermolysis bullosa. A consensus report by the subcommittee on diagnosis and classification of the national epidermolysis bullosa registry","volume":"24","author":"Fine","year":"1991","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/1523-1747.ep12371754_bb0020","series-title":"Connective Tissue and its Heritable Disorders. Molecular, Genetic and Medical Aspects","first-page":"507","article-title":"Epidermolysis bullosa","author":"Bruckner-Tuderman","year":"1993"},{"key":"10.1111\/1523-1747.ep12371754_bb0025","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/1523-1747.ep12598208","article-title":"Epidermolysis bullosa dystrophica-recessive: a possible role of the anchoring fibrils in the pathogenesis","volume":"65","author":"Briggaman","year":"1975","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12371754_bb0030","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF00567360","article-title":"Ultrastructural studies in epidermolysis bullosa hereditaria. III. Recessive dystrophic types with dermolytic blistering (Hallopeau-Siemens types and inverse type)","volume":"256","author":"Hashimoto","year":"1976","journal-title":"Arch Dermatol Res"},{"key":"10.1111\/1523-1747.ep12371754_bb0035","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/1523-1747.ep12265460","article-title":"Evaluation of anchoring fibrils and other components of the dermal-epidermal junction in dystrophic epidermolysis bullosa by a quantitative ultrastructural technique","volume":"84","author":"Tidman","year":"1985","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12371754_bb0040","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2133.1986.tb05707.x","article-title":"Identification of an epidermal basement membrane defect in recessive forms of dystrophic epidermolysis bullosa by LH7.2 monoclonal antibody: use in diagnosis","volume":"15","author":"Heagery","year":"1986","journal-title":"Br J Dermatol"},{"key":"10.1111\/1523-1747.ep12371754_bb0045","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000248673","article-title":"Lack of collagen VII in unaffected skin of patients with severe recessive dystrophic epidermolysis bullosa","volume":"176","author":"Bruckner-Tuderman","year":"1988","journal-title":"Dermatologica"},{"key":"10.1111\/1523-1747.ep12371754_bb0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/1523-1747.ep12277331","article-title":"Anchoring fibrils and type VII collagen are absent from skin in severe recessive dystrophic epidermolysis bullosa","volume":"93","author":"Bruckner-Tuderman","year":"1989","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12371754_bb0055","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/1523-1747.ep12555737","article-title":"Evidence for a structural abnormality of collagen VII in a patient with dystrophic epidermolysis bullosa inversa","volume":"98","author":"Bruckner-Tuderman","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12371754_bb0060","unstructured":"K\u00f6nig A., Raghunath M., Steinmann B., Bruckner-Tuderman L.: Dominant dystrophic epidermolysis bullosa: intracellular accumulation of collagen VII in keratinocytes leads to a reduced number of anchoring fibrils and skin blistering. J Invest Dermatol. in press"},{"key":"10.1111\/1523-1747.ep12371754_bb0065","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1172\/JCI115680","article-title":"Genetic linkage of type VII collagen (COL7A1) to dominant dystrophic epidermolysis bullosa in families with abnormal anchoring fibrils","volume":"89","author":"Ryyn\u00e4nen","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1111\/1523-1747.ep12371754_bb0070","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1172\/JCI115916","article-title":"Genetic linkage of recessive dystrophic epidermolysis bullosa to the type VII collagen gene","volume":"90","author":"Hovnanian","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1111\/1523-1747.ep12371754_bb0075","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1600-0625.1992.tb00001.x","article-title":"Pathogenesis of mechanobullous disorders","volume":"1","author":"Bruckner-Tuderman","year":"1992","journal-title":"Exp Dermatol"},{"key":"10.1111\/1523-1747.ep12371754_bb0080","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/1523-1747.ep12712167","article-title":"The carboxyterminal domain of type VII collagen is present at the basement membrane in recessive dystrophic epidermolysis bullosa","volume":"92","author":"Rusenko","year":"1989","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12371754_bb0085","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/1523-1747.ep12614773","article-title":"Keratinocytes and fibroblasts from a patient with mutilating dystrophic epidermolysis bullosa synthesize drastically reduced amounts of collagen VII: lack of effect of transforming growth factor-\u03b2","volume":"99","author":"K\u00f6nig","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12371754_bb0090","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1073\/pnas.74.10.4646","article-title":"Recessive dystrophic epidermolysis bullosa: evidence for an altered collagenase in fibroblast cultures","volume":"74","author":"Bauer","year":"1977","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/1523-1747.ep12371754_bb0095","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/1523-1747.ep13071274","article-title":"Collagenase expression in skin fibroblasts from families with recessive dystrophic epidermolysis bullosa","volume":"92","author":"Winberg","year":"1989","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12371754_bb0100","first-page":"74","article-title":"Sixteen types of epidermolysis bullosa. On the clinical discrimination, therapy and prenatal diagnosis","volume":"95","author":"Gedde-Dahl","year":"1981","journal-title":"Acta Dermato Vernerol (Stockh)"},{"key":"10.1111\/1523-1747.ep12371754_bb0105","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/1523-1747.ep12540422","article-title":"Calcium regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture","volume":"81","author":"Boyce","year":"1983","journal-title":"J Invest Dermtol"},{"key":"10.1111\/1523-1747.ep12371754_bb0110","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0003-2697(82)90292-5","article-title":"A rapid in situ deoxyribonucleic acid assay for determining cell number in cultures and tissue","volume":"122","author":"Johnson-Wine","year":"1982","journal-title":"Anal Biochem"},{"key":"10.1111\/1523-1747.ep12371754_bb0115","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1432-1033.1987.tb11483.x","article-title":"Tissue form of type VII collagen from human skin and fibroblasts in culture","volume":"165","author":"Bruckner-Tuderman","year":"1987","journal-title":"Eur J Biochem"},{"key":"10.1111\/1523-1747.ep12371754_bb0120","first-page":"17","article-title":"LH 7.2 monoclonal antibody detects type VII collagen in the basement membrane of ectodermally derived epithelia including skin","volume":"1","author":"Leigh","year":"1987","journal-title":"Epithelia"},{"key":"10.1111\/1523-1747.ep12371754_bb0125","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/1523-1747.ep12277377","article-title":"Epidermolysis bullosa acquisita antigen is synthesized by both human keratinocytes and human dermal fibroblasts","volume":"85","author":"Stanley","year":"1985","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12371754_bb0130","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/1523-1747.ep12259692","article-title":"Differentiating anti-lamina lucida and anti-sublamina densa anti-BMZ antibodies by indirect immunofluorescence on 1.0M sodium chloride separated skin","volume":"82","author":"Gammon","year":"1984","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12371754_bb0135","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"L\u00e4mmli","year":"1970","journal-title":"Nature"},{"key":"10.1111\/1523-1747.ep12371754_bb0140","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/1523-1747.ep12371754_bb0145","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1083\/jcb.117.3.679","article-title":"Transforming growth factor-\u03b2 stimulates collagen VII expression by cutaneous cells in vitro","volume":"117","author":"K\u00f6nig","year":"1992","journal-title":"J Cell Biol"},{"key":"10.1111\/1523-1747.ep12371754_bb0150","series-title":"A laboratory manual","article-title":"Molecular cloning","author":"Sambrook","year":"1990"},{"key":"10.1111\/1523-1747.ep12371754_bb0155","doi-asserted-by":"crossref","first-page":"6931","DOI":"10.1073\/pnas.88.16.6931","article-title":"Human type VII collagen: cDNA cloning and chromosomal mapping of the gene","volume":"88","author":"Parente","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/1523-1747.ep12371754_bb0160","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/nar\/13.5.1431","article-title":"Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate dehadrogenase multigenic family","volume":"13","author":"Fort","year":"1985","journal-title":"Nucl Acid Res"},{"key":"10.1111\/1523-1747.ep12371754_bb0165","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0006-291X(75)90243-0","article-title":"Collagenase production by human skin fibroblasts","volume":"64","author":"Bauer","year":"1975","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/1523-1747.ep12371754_bb0170","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/1523-1747.ep12524396","article-title":"Gelatinase expression generalized epidermolysis bullosa simplex fibroblasts","volume":"87","author":"Winberg","year":"1986","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12371754_bb0175","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/BF00569330","article-title":"Epidermolysis bullosa simplex: expression of gelatinase activity in cultured human skin fibroblasts","volume":"30","author":"Winberg","year":"1992","journal-title":"Biochem Genet"},{"key":"10.1111\/1523-1747.ep12371754_bb0180","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1749-6632.1990.tb17915.x","article-title":"The structure and function of type VII collagen","volume":"580","author":"Burgeson","year":"1990","journal-title":"Ann NY Acad Sci"},{"key":"10.1111\/1523-1747.ep12371754_bb0185","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/ng0692-214","article-title":"Evidence for a relationship between Ehlers-Danlos type VII C in humans and bovine dermatosparaxis","volume":"1","author":"Nusgens","year":"1992","journal-title":"Nature Genet"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X9497750X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X9497750X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:29:18Z","timestamp":1549412958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X9497750X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,2]]}},"alternative-id":["S0022202X9497750X"],"URL":"https:\/\/doi.org\/10.1111\/1523-1747.ep12371754","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[1994,2]]}}}