{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:20:27Z","timestamp":1779261627674,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1992,5,1]],"date-time":"1992-05-01T00:00:00Z","timestamp":704678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":8615,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[1992,5]]},"DOI":"10.1111\/1523-1747.ep12499896","type":"journal-article","created":{"date-parts":[[2004,7,15]],"date-time":"2004-07-15T14:41:41Z","timestamp":1089902501000},"page":"673-679","source":"Crossref","is-referenced-by-count":100,"title":["Differential Regulation of Retinoic Acid Receptors and Binding Proteins in Human Skin"],"prefix":"10.1016","volume":"98","author":[{"given":"James T","family":"Elder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"\u00c5str\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrika","family":"Pettersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Tavakkol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher E M","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andree","family":"Krust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Kastner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Chambon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J","family":"Voorhees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/1523-1747.ep12499896_bb0010","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0092-8674(81)90169-0","article-title":"Regulation of terminal differentiation of cultured human keratinocytes by vitamin A","volume":"25","author":"Fuchs","year":"1981","journal-title":"Cell"},{"key":"10.1111\/1523-1747.ep12499896_bb0015","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/1523-1747.ep12520026","article-title":"Retinoic acid delays the terminal differentiation of keratinocytes in suspension culture","volume":"76","author":"Yaar","year":"1981","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12499896_bb0020","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/1523-1747.ep12470632","article-title":"Cellular, immunologic and biochemical characterization of topical retinoic acid-treated human skin","volume":"96","author":"Fisher","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12499896_bb0025","first-page":"5174","article-title":"The induction of ornithine decarboxylase activity and DNA systhesis in hairless mouse epidermis by retinoids","volume":"43","author":"Connot","year":"1983","journal-title":"Cancer Res"},{"key":"10.1111\/1523-1747.ep12499896_bb0030","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/330444a0","article-title":"A human retinoic acid receptor which belongs to the family of nuclear receptors","volume":"330","author":"Petkovich","year":"1987","journal-title":"Nature"},{"key":"10.1111\/1523-1747.ep12499896_bb0035","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/331091a0","article-title":"Identification of a new class of steroid hormone receptors","volume":"331","author":"Giguere","year":"1988","journal-title":"Nature"},{"key":"10.1111\/1523-1747.ep12499896_bb0040","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1073\/pnas.86.14.5310","article-title":"A third human retinoic acid receptor, hRAR-3","volume":"86","author":"Krust","year":"1989","journal-title":"Proc Nad Acad Sci USA"},{"key":"10.1111\/1523-1747.ep12499896_bb0045","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/1523-1747.ep12469889","article-title":"Retinoic acid receptor gene expression in human skin","volume":"96","author":"Elder","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12499896_bb0050","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/339714a0","article-title":"Cloning of murine \u03b1 and \u03b2 retinoic acid receptors and a novel receptor \u03b3 predominantly expressed in skin","volume":"339","author":"Zelent","year":"1989","journal-title":"Nature"},{"key":"10.1111\/1523-1747.ep12499896_bb0055","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/345224a0","article-title":"Nuclear receptor that identifies a novel retinoic acid response pathway","volume":"345","author":"Mangelsdorf","year":"1990","journal-title":"Nature"},{"key":"10.1111\/1523-1747.ep12499896_bb0060","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/1523-1747.ep12283594","article-title":"Cell kinetic basis for pathophysiology of psoriasis","volume":"85","author":"Weinstein","year":"1985","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12499896_bb0065","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/1523-1747.ep12462014","article-title":"Abnormal sequence of expression of differentiation markers in psoriatic epidermis: inversion of two steps in the differentiation program","volume":"90","author":"Bernard","year":"1988","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12499896_bb0070","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1432-1033.1987.tb13503.x","article-title":"A slab gel electrophoresis technique for measurement of plasma retinol-binding protein, cellular retinol-binding and retinoic-acid-binding proteins in human skin","volume":"166","author":"Siegenthaler","year":"1987","journal-title":"Eur J Biochem"},{"key":"10.1111\/1523-1747.ep12499896_bb0075","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0006-291X(05)81062-9","article-title":"Retinoic acid and synthetic analogs differentially activate retinoic acid receptor dependent transcription","volume":"173","author":"\u00c5str\u00f6m","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/1523-1747.ep12499896_bb0080","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0012-1606(89)90163-2","article-title":"Cellular retinoic acid-binding protein and the role of retinoic acid in the development of the chick embryo","volume":"135","author":"Maden","year":"1989","journal-title":"Dev Biology"},{"key":"10.1111\/1523-1747.ep12499896_bb0085","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/335733a0","article-title":"Spatial distribution of cellular protein binding to retinoic acid in the chick limb bud","volume":"335","author":"Maden","year":"1988","journal-title":"Nature"},{"key":"10.1111\/1523-1747.ep12499896_bb0090","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0006-291X(90)91992-2","article-title":"Spatial and temporal expression of cellular retinoic acid binding protein (CRABP) along the anteroposterior axis in the central nervous system of mouse embryos","volume":"169","author":"Momoi","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/1523-1747.ep12499896_bb0095","first-page":"1497","article-title":"Mouse cellular retinoic acid binding protein: cloning, complementary DNA sequence, and messenger RNA expression during the retinoic acid-induced differentiation of F9 wilt type and RA-3-10 mutant teratocarcinoma cells","volume":"49","author":"Stoner","year":"1989","journal-title":"Cancer Res"},{"key":"10.1111\/1523-1747.ep12499896_bb0100","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1073\/pnas.87.16.6233","article-title":"Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein","volume":"87","author":"Giguere","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/1523-1747.ep12499896_bb0105","doi-asserted-by":"crossref","first-page":"9326","DOI":"10.1016\/S0021-9258(19)76544-2","article-title":"Purification and partial characterization of a novel binding protein for retinoic acid from neonatal rat","volume":"263","author":"Bailey","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12499896_bb0110","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1073\/pnas.84.16.5645","article-title":"Molecular cloning and analysis of functional cDNA and genomic clones encoding bovine cellular retinoic acid-binding protein","volume":"84","author":"Shubeita","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/1523-1747.ep12499896_bb0115","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S0006-291X(88)81016-7","article-title":"The presence of a novel cellular retinoic acid-binding protein in chick embryos: purification and partial characterization","volume":"157","author":"Kitamoto","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/1523-1747.ep12499896_bb0120","first-page":"17662","article-title":"Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP)","volume":"266","author":"\u00c5str\u00f6m","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12499896_bb0125","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1073\/pnas.87.7.2700","article-title":"Murine isoforms of retinoic acid receptor y with specific patterns of expression","volume":"87","author":"Kastner","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/1523-1747.ep12499896_bb0130","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/j.1460-2075.1991.tb07921.x","article-title":"Multiple isoforms of the mouse retinoic acid receptor y are generated by alternative splicing and differential induction by retinoic acid","volume":"10","author":"Leroy","year":"1991","journal-title":"Embo J"},{"key":"10.1111\/1523-1747.ep12499896_bb0135","first-page":"701","article-title":"Decreased cyclic AMP in the epidermis of lesions of psoriasis","volume":"105","author":"Voorhces","year":"1972","journal-title":"Arch Derm"},{"key":"10.1111\/1523-1747.ep12499896_bb0140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/1523-1747.ep12873313","article-title":"Protooncogene expression in normal and psoriatic skin","volume":"94","author":"Elder","year":"1990","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12499896_bb0145","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1073\/pnas.74.12.5463","article-title":"DNA sequencing with chain-terminating inhibitors","volume":"74","author":"Sanger","year":"1977","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/1523-1747.ep12499896_bb0150","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1128\/MCB.6.11.3614","article-title":"Coding sequence and growth regulation of the human vimentin gene","volume":"6","author":"Ferrari","year":"1986","journal-title":"Mol Cell Biol"},{"key":"10.1111\/1523-1747.ep12499896_bb0155","first-page":"618A","article-title":"A highly differentiated organotypic skin model for dermatologic, pharmacologic, and toxicologic research","volume":"96","author":"Bilbo","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12499896_bb0160","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/1523-1747.ep12523628","article-title":"Therapy with a synthetic retinoid-(Ro 10-1670) Etretin-increases the cellular retinoic acid-binding protein in nonlesional psoriatic skin","volume":"87","author":"Siegenthaler","year":"1986","journal-title":"J Invest Dermol"},{"key":"10.1111\/1523-1747.ep12499896_bb0165","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0014-4827(88)90383-7","article-title":"Terminal differentiation in cultured human keratinocytes is associated with increased levels of cellular retinoic acid-binding protein","volume":"178","author":"Siegenthaler","year":"1988","journal-title":"Exp Cell Res"},{"key":"10.1111\/1523-1747.ep12499896_bb0170","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1365-2362.1989.tb00221.x","article-title":"Ligand-specific and non-specific in vivo modulation of human epidermal cellular retinoic acid binding protein (CRABP)","volume":"19","author":"Hirschel-Scholz","year":"1989","journal-title":"Eur J Clin Invest"},{"key":"10.1111\/1523-1747.ep12499896_bb0175","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/jcp.1041430213","article-title":"Calcium regulation of growth and differentiation of normal human keratinocytes: modulation of differentiation competence by stages of growth and extracellular calcium","volume":"143","author":"Pillai","year":"1990","journal-title":"J Cell Phys"},{"key":"10.1111\/1523-1747.ep12499896_bb0180","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1042\/bj2080731","article-title":"Nuclear interactions of retinoic acid-binding protein in chemically induced mammary adenocarcinoma","volume":"208","author":"Mehta","year":"1982","journal-title":"Biochem J"},{"key":"10.1111\/1523-1747.ep12499896_bb0185","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0003-9861(86)90591-6","article-title":"Transfer of retinoic acid from its complex with cellular retinoic acid-binding protein to the nucleus","volume":"247","author":"Takase","year":"1986","journal-title":"Arch Biochem Biophys"},{"key":"10.1111\/1523-1747.ep12499896_bb0190","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1016\/S0021-9258(18)91100-2","article-title":"Selections and characterization of F9 Teratocarcinoma stem cell mutants with altered responses to retinoic acid","volume":"259","author":"Wang","year":"1984","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12499896_bb0195","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1083\/jcb.112.5.965","article-title":"Overexpression of the cellular retinoic acid binding protein-1 (CRABP-I) results in a reduction in differentiation-specific gene expression in F9 teratocarcinoma cells","volume":"112","author":"Boylan","year":"1991","journal-title":"J Cell Biol"},{"key":"10.1111\/1523-1747.ep12499896_bb0200","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1432-0436.1990.tb00476.x","article-title":"Filaggrin production by cultured human epidermal keratinocytes and its regulation by retinoic acid","volume":"45","author":"Asselineau","year":"1990","journal-title":"Differentiation"},{"key":"10.1111\/1523-1747.ep12499896_bb0205","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/1523-1747.ep12580383","article-title":"Effect of retinoic acid on cornified envelope formation: difference between spontanious envelope formation in vivo or in vitro and expression of envelope conpetence","volume":"89","author":"Nagae","year":"1987","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12499896_bb0210","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/1523-1747.ep12469779","article-title":"Transcription of the human loricrin gene in vitro is induced by calcium and cell density and suppressed by retinoic acid","volume":"96","author":"Hohl","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12499896_bb0215","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/1523-1747.ep12277374","article-title":"Action of phorbol esters, bryostatins, and retinoic acid on cholesterol sulfate synthesis: relation to the multistep process of differentiation in human epidermal keratinocytes","volume":"93","author":"Jetten","year":"1989","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12499896_bb0220","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/1523-1747.ep12504718","article-title":"Changes in photoaged human skin following topical application of all-trans retinoic acid","volume":"95","author":"Rosenthal","year":"1990","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12499896_bb0225","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/1523-1747.ep12485084","article-title":"Spreading of psoriatic plaques: alteration of epidermal differentiation precedes capillary leakiness and anomalies in vascular morphology","volume":"95","author":"Parent","year":"1990","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12499896_bb0230","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1346-8138.1991.tb03057.x","article-title":"Abnormal distribution of epidermal protein antigens in psoriatic epidermis","volume":"18","author":"Watanabe","year":"1991","journal-title":"J Dermatol"},{"key":"10.1111\/1523-1747.ep12499896_bb0235","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0006-291X(89)91705-1","article-title":"Increased membrane-associated transglutaminase activity in psoriasis","volume":"164","author":"Esmann","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/1523-1747.ep12499896_bb0240","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/1523-1747.ep12471751","article-title":"Measurement of the rate of epidermal terminal differentiation: expression of involucrin by S-phase keratinocytes in culture and in psoriatic plaques","volume":"89","author":"Dover","year":"1987","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12499896_bb0245","doi-asserted-by":"crossref","first-page":"16572","DOI":"10.1016\/S0021-9258(18)55339-4","article-title":"Expression of cellular retinoic acid binding protein in Eschericia coli: characterization and evidence that holo-CRABP is a substrate in retinoic acid metabolism","volume":"266","author":"Fiorella","year":"1991","journal-title":"J Biol Chem"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X9290137S?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X9290137S?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T06:42:01Z","timestamp":1624516921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X9290137S"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,5]]}},"alternative-id":["S0022202X9290137S"],"URL":"https:\/\/doi.org\/10.1111\/1523-1747.ep12499896","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[1992,5]]}}}