{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:40:20Z","timestamp":1787168420160,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1989,6,1]],"date-time":"1989-06-01T00:00:00Z","timestamp":612662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":9680,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[1989,6]]},"DOI":"10.1111\/1523-1747.ep12696808","type":"journal-article","created":{"date-parts":[[2004,7,19]],"date-time":"2004-07-19T11:09:51Z","timestamp":1090235391000},"page":"791-797","source":"Crossref","is-referenced-by-count":19,"title":["Increased Phosphatidylinositol Kinase Activity in Psoriatic Epidermis"],"prefix":"10.1016","volume":"92","author":[{"given":"Marilyn C.","family":"Pike","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.T.","family":"Elder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Voorhees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.J.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/1523-1747.ep12696808_bb0010","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.1073\/pnas.72.12.5130","article-title":"Increased concentrations of nonesterified arachidonic acid, 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2 and prostaglandin F2\u03b1 in epidermis of psoriasis","volume":"72","author":"Hammarstrom","year":"1975","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/1523-1747.ep12696808_bb0015","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/1523-1747.ep12273519","article-title":"Biosynthesis of lipoxygenase products by enzyme preparations from normal and psoriatic skin","volume":"83","author":"Ziboh","year":"1984","journal-title":"J. Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12696808_bb0020","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/1523-1747.ep12469836","article-title":"Partial characterization of phospholipase C activity in normal, psoriatic uninvolved and lesional epidermis","volume":"88","author":"Bartel","year":"1987","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12696808_bb0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1365-2133.1985.tb00077.x","article-title":"Characterization and activity of phospholipase A2 in normal human epidermis and in lesion-free epidermis of patients with psoriasis and eczema","volume":"112","author":"Forster","year":"1985","journal-title":"Br.J. Dermatol"},{"key":"10.1111\/1523-1747.ep12696808_bb0030","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/1523-1747.ep12525380","article-title":"Decreased protein kinase C activity in psoriatic versus normal epidermis","volume":"88","author":"Horn","year":"1987","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12696808_bb0035","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-4165(84)90009-6","article-title":"Protein tyrosine kinase and protein phosphotyrosine phosphatase in normal and psoriatic skin","volume":"798","author":"Gentleman","year":"1984","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/1523-1747.ep12696808_bb0040","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/1523-1747.ep12547095","article-title":"Glucocorticoid inhibits elevated polyamine biosynthesis in psoriasis","volume":"71","author":"Russell","year":"1978","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12696808_bb0045","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/1523-1747.ep12285389","article-title":"Altered [125I] epidermal growth factor binding and receptor distribution in psoriasis","volume":"86","author":"Nanney","year":"1986","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12696808_bb0050","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1042\/bj2200345","article-title":"Inositol trisphosphate and diacylglycerol as second messengers","volume":"220","author":"Berridge","year":"1984","journal-title":"Biochem J"},{"key":"10.1111\/1523-1747.ep12696808_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0303-7207(84)90024-8","article-title":"Phospholipids as intermediates in Hormone action","volume":"35","author":"Farese","year":"1984","journal-title":"Mol Cell Endocrinol"},{"key":"10.1111\/1523-1747.ep12696808_bb0060","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.3024320","article-title":"The metabolism of phosphoinositide-derived messenger molecules","volume":"234","author":"Majerus","year":"1986","journal-title":"Science"},{"key":"10.1111\/1523-1747.ep12696808_bb0065","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0003-9861(83)90514-3","article-title":"Properties of phosphatidylinositol kinase activities in rabbit erythrocyte membranes","volume":"222","author":"Quist","year":"1983","journal-title":"Arch Biochem Biophys"},{"key":"10.1111\/1523-1747.ep12696808_bb0070","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0005-2760(88)90183-X","article-title":"Phosphatidylinositol kinase, phosphatidylinositol-4-phosphate kinase and diacylglycerol kinase activities in rat brain subcellular fractions","volume":"958","author":"Stubbs","year":"1988","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/1523-1747.ep12696808_bb0075","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.4049\/jimmunol.140.6.1967","article-title":"Characterization of phosphatidylinositol and phosphatidylinositol-4-phosphate kinases in human neutrophils","volume":"140","author":"Pike","year":"1988","journal-title":"J Immunol"},{"key":"10.1111\/1523-1747.ep12696808_bb0080","doi-asserted-by":"crossref","first-page":"17285","DOI":"10.1016\/S0021-9258(18)45375-6","article-title":"Epidermal growth factor and angiotensin II stimulate formation of inositol, 1,4,5- and inositol 1,3,4-trisphosphate in hepatocytes. Differential inhibition by pertussis toxin and phorbol 12-myristate 13-acetate","volume":"262","author":"Johnson","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12696808_bb0085","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0021-9258(19)75685-3","article-title":"Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells","volume":"262","author":"Pike","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12696808_bb0090","doi-asserted-by":"crossref","first-page":"6280","DOI":"10.1021\/bi00524a057","article-title":"Enhancement of calcium uptake and phosphatidylinositol turnover A-431 cells","volume":"20","author":"Sawyer","year":"1981","journal-title":"Biochemistry"},{"key":"10.1111\/1523-1747.ep12696808_bb0095","doi-asserted-by":"crossref","first-page":"8824","DOI":"10.1016\/S0021-9258(17)39426-7","article-title":"Separation and characterization of a phosphatidylinositol kinase activity that copurifies with the epidermal growth factor receptor","volume":"260","author":"Thompson","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12696808_bb0100","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0092-8674(87)90168-1","article-title":"Common elements in growth factor stimulation and oncogenic transformation: 85 Kd phosphoprotein and phosphatidylinositol kinase activity","volume":"50","author":"Kaplan","year":"1987","journal-title":"Cell"},{"key":"10.1111\/1523-1747.ep12696808_bb0105","doi-asserted-by":"crossref","first-page":"7513","DOI":"10.1073\/pnas.84.21.7513","article-title":"Phosphatidylinositol kinase is activated in membranes derived from cells treated with epidermal growth factor","volume":"84","author":"Walker","year":"1987","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1111\/1523-1747.ep12696808_bb0110","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0076-6879(81)72054-8","article-title":"Extraction and purification of polyphosphoinositides","volume":"72","author":"Schact","year":"1981","journal-title":"Methods Enzymol"},{"key":"10.1111\/1523-1747.ep12696808_bb0115","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0076-6879(67)12127-7","article-title":"Determination of DNA concentration with diphenylamine","volume":"12","author":"Burton","year":"1968","journal-title":"Methods Enzymol"},{"key":"10.1111\/1523-1747.ep12696808_bb0120","doi-asserted-by":"crossref","first-page":"971","DOI":"10.4049\/jimmunol.137.3.971","article-title":"Identification and characterization of the phosphatidylinositol kinase in membranes of murine T lymphocytes","volume":"137","author":"O'Shea","year":"1986","journal-title":"J Immunol"},{"key":"10.1111\/1523-1747.ep12696808_bb0125","doi-asserted-by":"crossref","first-page":"616","DOI":"10.4049\/jimmunol.136.2.616","article-title":"A phosphatidylinositol kinase in rat mast cell granules","volume":"136","author":"Kurosawa","year":"1986","journal-title":"J Immunol"},{"key":"10.1111\/1523-1747.ep12696808_bb0130","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1042\/bj2470165","article-title":"Evidence for two distinct phosphatidylinositol kinases in fibroblasts","volume":"247","author":"Whitman","year":"1987","journal-title":"Biochem J"},{"key":"10.1111\/1523-1747.ep12696808_bb0135","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0005-2760(88)90185-3","article-title":"Phosphitidylinositol and phosphatidylinositol phosphate kinases in plant plasma membranes","volume":"958","author":"Sommarin","year":"1988","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/1523-1747.ep12696808_bb0140","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1432-1033.1986.tb09390.x","article-title":"Polyamines stimulate the phosphorylation of phos phatidylinositol in membranes from A-431 cells","volume":"154","author":"Vogel","year":"1986","journal-title":"Eur J Biochem"},{"key":"10.1111\/1523-1747.ep12696808_bb0145","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1016\/S0021-9258(19)83645-1","article-title":"Adenosine and 5'-chlorodeoxyadenosine inhibit the phosphorylation of phosphatidylinositol and myosin light chain in calf aorta smooth muscle","volume":"260","author":"Doctrow","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12696808_bb0150","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1016\/S0021-9258(18)68966-5","article-title":"Inhibition of phosphoinositide metabolism in human polymorphonuclear leukocytes by S-adenosylhomocysteine","volume":"263","author":"Pike","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1111\/1523-1747.ep12696808_bb0155","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1001\/jama.1986.03380220076026","article-title":"Cyclosporine improves psoriasis in a double-blind study","volume":"256","author":"Ellis","year":"1986","journal-title":"JAMA"},{"key":"10.1111\/1523-1747.ep12696808_bb0160","doi-asserted-by":"crossref","DOI":"10.1111\/1523-1747.ep12464387","article-title":"Levels of cyclosporin in epidermis of treated psoriasis patients differentially inhibit growth of keratinocytes cultured in serum free versus serum containing media","author":"Fisher","year":"1988","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12696808_bb0165","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1365-2133.1973.tb02986.x","article-title":"Initial events in psoriasis: quantitative assessment","volume":"89","author":"Christophers","year":"1973","journal-title":"Brit J Dermatol"},{"key":"10.1111\/1523-1747.ep12696808_bb0170","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/S0140-6736(82)91365-4","article-title":"Chemotactic leukocrienes in psoriasis","volume":"2","author":"Grabbe","year":"1982","journal-title":"Lancet"},{"key":"10.1111\/1523-1747.ep12696808_bb0175","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/1523-1747.ep12523566","article-title":"Identification of C5a desarg and an anionic neutrophil-activating peptide (ANAP) in psoriatic scales","volume":"87","author":"Schroder","year":"1986","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12696808_bb0180","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1126\/science.929193","article-title":"Polymorphonuclear leukocytes: possible mechanism of accumulation in psoriasis","volume":"198","author":"Lazarus","year":"1977","journal-title":"Science"},{"key":"10.1111\/1523-1747.ep12696808_bb0185","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00000372-197900130-00002","article-title":"Evolution, maturation and regression of lesions of psoriasis","volume":"1","author":"Ragaz","year":"1979","journal-title":"Am J Dermatopathol"},{"key":"10.1111\/1523-1747.ep12696808_bb0190","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/1523-1747.ep12529841","article-title":"Characterization of mononuclear infiltrates in psoriatic lesions","volume":"71","author":"Bjerke","year":"1978","journal-title":"J Invest Dermatol"},{"key":"10.1111\/1523-1747.ep12696808_bb0195","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1432-1033.1985.tb09118.x","article-title":"Evidence that treatment of platelets with phorbol esters causes proteolytic activation of Ca++ activated phospholipid dependent protein kinase","volume":"151","author":"Tapley","year":"1985","journal-title":"Eur J Biochem"},{"key":"10.1111\/1523-1747.ep12696808_bb0200","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0014-5793(85)80425-7","article-title":"Rapid down-regulation of protein kinase C and membrane association in phorbol ester-treated leukemia cells","volume":"190","author":"Wickemasinghe","year":"1985","journal-title":"FEBS Lett"},{"key":"10.1111\/1523-1747.ep12696808_bb0205","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/332644a0","article-title":"Type 1 phosphatidylinositol kinase makes a novel inositol phospholipid phosphatidylinositol-3-phosphate","volume":"332","author":"Whitman","year":"1988","journal-title":"Nature"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X89903151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X89903151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T17:40:53Z","timestamp":1705167653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X89903151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,6]]}},"alternative-id":["S0022202X89903151"],"URL":"https:\/\/doi.org\/10.1111\/1523-1747.ep12696808","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[1989,6]]}}}