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However, concerns about disorders related to the consumption of wheat and\/or wheat gluten proteins have increased sharply in the last 20 years. This review focuses on wheat gluten proteins and amylase trypsin inhibitors, which are considered to be responsible for eliciting most of the intestinal and extraintestinal symptoms experienced by susceptible individuals. Although several approaches have been proposed to reduce the exposure to gluten or immunogenic peptides resulting from its digestion, none have proven sufficiently effective for general use in coeliac\u2010safe diets. Potential approaches to manipulate the content, composition, and technological properties of wheat proteins are therefore discussed, as well as the effects of using gluten isolates in various food systems. Finally, some aspects of the use of gluten\u2010free commodities are discussed.<\/jats:p>","DOI":"10.1111\/1541-4337.12493","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T03:39:01Z","timestamp":1568000341000},"page":"1751-1769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Wheat Seed Proteins: Factors Influencing Their Content, Composition, and Technological Properties, and Strategies to Reduce Adverse Reactions"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-9501","authenticated-orcid":false,"given":"Sachin","family":"Rustgi","sequence":"first","affiliation":[{"name":"Dept. of Plant and Environmental Sciences, School of Health Research Clemson Univ. Pee Dee Research and Education Centre  Florence SC U.S.A."},{"name":"Dept. of Crop and Soil Sciences Washington State Univ.  Pullman WA U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Shewry","sequence":"additional","affiliation":[{"name":"Rothamsted Research  Harpenden Hertfordshire U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5907-8388","authenticated-orcid":false,"given":"Fred","family":"Brouns","sequence":"additional","affiliation":[{"name":"Dept. of Human Biology, School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences Maastricht Univ.  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