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Numerous mineral ligands are found in both animal and plant foods and are known to exert bioactivity\n                    <jats:italic>via<\/jats:italic>\n                    element chelation resulting in modulation of antioxidant capacity or micobiome metabolism among other physiological outcomes. However, little is explored in the context of dietary mineral ligands and element bioavailability enhancement, particularly with respect to ligands from plant\u2010derived food sources. This review highlights a novel perspective to consider various plant macro\/micronutrients as prospective bioavailability enhancing ligands of three essential elements (Fe, Zn, and Ca). We also delineate the molecular mechanisms of the ligand\u2010binding interactions underlying mineral bioaccessibility at the luminal level. We conclude that despite current understandings of some of the structure\u2013activity relationships associated with strong mineral\u2013ligand binding, the physiological links between ligands as element carriers and uptake at targeted sites throughout the gastrointestinal (GI) tract still require more research. The binding behavior of potential ligands in the human diet should be further elucidated and validated using pharmacokinetic approaches and GI models.\n                  <\/jats:p>","DOI":"10.1111\/1541-4337.12669","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T21:48:58Z","timestamp":1606168138000},"page":"652-685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Opportunities for plant\u2010derived enhancers for iron, zinc, and calcium bioavailability: A review"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-8477","authenticated-orcid":false,"given":"Yianna Y.","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Agriculture and Food, Faculty of Veterinary and Agricultural Sciences The University of Melbourne  Parkville VIC Australia"},{"name":"CSIRO Agriculture &amp; Food  Werribee VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regine","family":"Stockmann","sequence":"additional","affiliation":[{"name":"CSIRO Agriculture &amp; Food  Werribee VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1843-0506","authenticated-orcid":false,"given":"Ken","family":"Ng","sequence":"additional","affiliation":[{"name":"School of Agriculture and Food, Faculty of Veterinary and Agricultural Sciences The University of Melbourne  Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6896-5509","authenticated-orcid":false,"given":"Said","family":"Ajlouni","sequence":"additional","affiliation":[{"name":"School of Agriculture and Food, Faculty of Veterinary and Agricultural Sciences The University of Melbourne  Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.116936"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.04.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12161-015-0387-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813768-0.00004-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/33.6.1314"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2002.128146"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmz004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2005.05.044"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2011.11.020"},{"key":"e_1_2_8_11_1","volume-title":"Elemental speciation in human health risk assessment","author":"Apostoli P.","year":"2006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/bk-1991-0445.ch024"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040871"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62304-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00237.2009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2008.00673.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.5917"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2014.953030"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.13074"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071502"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57598-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i14.2083"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12105"},{"key":"e_1_2_8_24_1","first-page":"8","volume-title":"Food chemistry","author":"Belitz H.\u2010D.","year":"2009"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300208"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-food-030713-092346"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655202320378176"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:2004053"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.1.9"},{"key":"e_1_2_8_30_1","first-page":"S99","article-title":"International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. 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