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Through its gene expression reprogramming and production of compounds that inactivate the growth of other microorganisms,\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    is able to grow in adverse environments and in complex microbial consortia, as in fruit pulps and root flour fermentations. The distinct set of up\u2010regulated genes throughout yeast biomass propagation includes those involved in sugar fermentation, ethanol metabolization, and in protective responses against abiotic stresses. These high abundant proteins are precursors of several peptides with promising health\u2010beneficial activities such as antihypertensive, antioxidant, antimicrobial, immunomodulatory, anti\u2010obesity, antidiabetes, and mitogenic properties. An in silico investigation of these\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    derived peptides produced during yeast biomass propagation or induced by physicochemical treatments were performed using four algorithms to predict antimicrobial candidates encrypted in abundantly expressed stress\u2010related proteins encoded by different genes like\n                    <jats:italic>AHP1, TSA1, HSP26, SOD1<\/jats:italic>\n                    ,\n                    <jats:italic>HSP10<\/jats:italic>\n                    , and\n                    <jats:italic>UTR2<\/jats:italic>\n                    , or metabolic enzymes involved in carbon source utilization, like\n                    <jats:italic>ENO1\/2, TDH1\/2\/3, ADH1\/2, FBA1<\/jats:italic>\n                    , and\n                    <jats:italic>PDC1<\/jats:italic>\n                    . Glyceraldehyde\u20103\u2010phosphate dehydrogenase and enolase II are noteworthy precursor proteins, since they exhibited the highest scores concerning the release of antimicrobial peptide candidates. Considering the set of genes upregulated during biomass propagation, we conclude that\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    biomass, a food\u2010grade product consumed and marketed worldwide, should be considered a safe and nonseasonal source for designing next\u2010generation bioactive agents, especially protein encrypting antimicrobial peptides that display broad spectra activity and could reduce the emergence of microbial resistance while also avoiding cytotoxicity.\n                  <\/jats:p>","DOI":"10.1111\/1541-4337.12798","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T03:35:26Z","timestamp":1628652926000},"page":"4450-4479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["<i>Saccharomyces cerevisiae<\/i>\n                    biomass as a source of next\u2010generation food preservatives: Evaluating potential proteins as a source of antimicrobial peptides"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9008-9904","authenticated-orcid":false,"given":"Patricia R.","family":"Pereira","sequence":"first","affiliation":[{"name":"Chemistry Institute Federal University of Rio de Janeiro (UFRJ)  Av. Athos da Silveira Ramos, 149 Rio de Janeiro 21941\u2010909 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyntia S.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Chemistry Institute Federal University of Rio de Janeiro (UFRJ)  Av. Athos da Silveira Ramos, 149 Rio de Janeiro 21941\u2010909 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6093-134X","authenticated-orcid":false,"given":"Vania M. F.","family":"Paschoalin","sequence":"additional","affiliation":[{"name":"Chemistry Institute Federal University of Rio de Janeiro (UFRJ)  Av. 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